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The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis
To evaluate the effectiveness of exercise for improving bone-related outcomes among cancer survivors. Systematic review and meta-analysis. An electronic search using the following databases: SPORTDiscus, Science Direct, CINAHL, MEDLINE, Cochrane, Pubmed, Ebscohost, ProQuest Nursing and Allied Health...
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| Published in: | Journal of science and medicine in sport 2022-01, Vol.25 (1), p.31-40 |
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| container_title | Journal of science and medicine in sport |
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| creator | Singh, Benjamin Toohey, Kellie |
| description | To evaluate the effectiveness of exercise for improving bone-related outcomes among cancer survivors.
Systematic review and meta-analysis.
An electronic search using the following databases: SPORTDiscus, Science Direct, CINAHL, MEDLINE, Cochrane, Pubmed, Ebscohost, ProQuest Nursing and Allied Health Source.
Randomised, controlled, exercise trials involving cancer survivors were eligible. Effect data on bone mineral content (BMC) and density (BMD) outcomes were extracted. Risk of bias was assessed using the Physiotherapy Evidence Database tool. Standardised mean differences (SMD) were calculated to compare differences between exercise and usual care. Subgroup analyses were conducted to assess whether effect differed by exercise mode, intervention length, supervision, treatment, cancer type and risk of bias.
Twenty-six trials were included, with intervention durations ranging between 12 weeks and 2 years. Most trials involved breast cancer (n = 13, 50%), and most interventions were supervised (n = 18, 69%) and evaluated mixed-mode (i.e., combined aerobic and resistance) exercise (n = 13, 50%). Significant effects in favour of exercise (aerobic, resistance, mixed-mode and other exercise) were observed for whole body BMD, hip BMD, trochanter BMD and femoral neck BMD (SMD range: 0.19–0.39, all p |
| doi_str_mv | 10.1016/j.jsams.2021.08.008 |
| format | article |
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Systematic review and meta-analysis.
An electronic search using the following databases: SPORTDiscus, Science Direct, CINAHL, MEDLINE, Cochrane, Pubmed, Ebscohost, ProQuest Nursing and Allied Health Source.
Randomised, controlled, exercise trials involving cancer survivors were eligible. Effect data on bone mineral content (BMC) and density (BMD) outcomes were extracted. Risk of bias was assessed using the Physiotherapy Evidence Database tool. Standardised mean differences (SMD) were calculated to compare differences between exercise and usual care. Subgroup analyses were conducted to assess whether effect differed by exercise mode, intervention length, supervision, treatment, cancer type and risk of bias.
Twenty-six trials were included, with intervention durations ranging between 12 weeks and 2 years. Most trials involved breast cancer (n = 13, 50%), and most interventions were supervised (n = 18, 69%) and evaluated mixed-mode (i.e., combined aerobic and resistance) exercise (n = 13, 50%). Significant effects in favour of exercise (aerobic, resistance, mixed-mode and other exercise) were observed for whole body BMD, hip BMD, trochanter BMD and femoral neck BMD (SMD range: 0.19–0.39, all p < 0.05) compared to usual care.
Participation in various modes (aerobic, resistance, mixed-mode and other) of supervised and unsupervised exercise is associated with improvements in BMD. The present results provide evidence for clinicians and other health care professionals (e.g., exercise physiologists and physiotherapists) to recommend exercise for cancer survivors to prevent bone loss during and following treatment.</description><identifier>ISSN: 1440-2440</identifier><identifier>EISSN: 1878-1861</identifier><identifier>DOI: 10.1016/j.jsams.2021.08.008</identifier><identifier>PMID: 34465518</identifier><language>eng</language><publisher>Australia: Elsevier Ltd</publisher><subject>Aerobic exercise ; Bias ; Bone ; Bone Density ; Breast cancer ; Breast Neoplasms - therapy ; Cancer Survivors ; Cancer therapies ; Chemotherapy ; Endocrine therapy ; Exercise ; Exercise intensity ; Exercise oncology ; Exercise Therapy ; Female ; Fractures ; Humans ; Intervention ; Meta-analysis ; Neoplasm ; Osteoporosis ; Physical fitness ; Prostate cancer ; Quality of life ; Resistance exercise ; Software ; Supervision ; Systematic review</subject><ispartof>Journal of science and medicine in sport, 2022-01, Vol.25 (1), p.31-40</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-24e927d52b6b8fc199be15395433d6b77eb7696ee9acfce9bbc3627d660aae233</citedby><cites>FETCH-LOGICAL-c387t-24e927d52b6b8fc199be15395433d6b77eb7696ee9acfce9bbc3627d660aae233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34465518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Benjamin</creatorcontrib><creatorcontrib>Toohey, Kellie</creatorcontrib><title>The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis</title><title>Journal of science and medicine in sport</title><addtitle>J Sci Med Sport</addtitle><description>To evaluate the effectiveness of exercise for improving bone-related outcomes among cancer survivors.
Systematic review and meta-analysis.
An electronic search using the following databases: SPORTDiscus, Science Direct, CINAHL, MEDLINE, Cochrane, Pubmed, Ebscohost, ProQuest Nursing and Allied Health Source.
Randomised, controlled, exercise trials involving cancer survivors were eligible. Effect data on bone mineral content (BMC) and density (BMD) outcomes were extracted. Risk of bias was assessed using the Physiotherapy Evidence Database tool. Standardised mean differences (SMD) were calculated to compare differences between exercise and usual care. Subgroup analyses were conducted to assess whether effect differed by exercise mode, intervention length, supervision, treatment, cancer type and risk of bias.
Twenty-six trials were included, with intervention durations ranging between 12 weeks and 2 years. Most trials involved breast cancer (n = 13, 50%), and most interventions were supervised (n = 18, 69%) and evaluated mixed-mode (i.e., combined aerobic and resistance) exercise (n = 13, 50%). Significant effects in favour of exercise (aerobic, resistance, mixed-mode and other exercise) were observed for whole body BMD, hip BMD, trochanter BMD and femoral neck BMD (SMD range: 0.19–0.39, all p < 0.05) compared to usual care.
Participation in various modes (aerobic, resistance, mixed-mode and other) of supervised and unsupervised exercise is associated with improvements in BMD. The present results provide evidence for clinicians and other health care professionals (e.g., exercise physiologists and physiotherapists) to recommend exercise for cancer survivors to prevent bone loss during and following treatment.</description><subject>Aerobic exercise</subject><subject>Bias</subject><subject>Bone</subject><subject>Bone Density</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer Survivors</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Endocrine therapy</subject><subject>Exercise</subject><subject>Exercise intensity</subject><subject>Exercise oncology</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Fractures</subject><subject>Humans</subject><subject>Intervention</subject><subject>Meta-analysis</subject><subject>Neoplasm</subject><subject>Osteoporosis</subject><subject>Physical fitness</subject><subject>Prostate cancer</subject><subject>Quality of life</subject><subject>Resistance exercise</subject><subject>Software</subject><subject>Supervision</subject><subject>Systematic review</subject><issn>1440-2440</issn><issn>1878-1861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kb9u1TAUxi0EoqXwBEjIEgtLwrGdOPbAUFUUkCqxlNmynROuoyQudnLL3XgInpAnqcstDAwsPh5-3_nzfYS8ZFAzYPLtWI_ZzrnmwFkNqgZQj8gpU52qmJLscfk3DVS8PCfkWc4jAG870T0lJ6JpZNsydUqW6x1SHAb0K40Dxe-YfMhIh5homG9S3IflK3VxQbpDO607Ghbq7eIx0bylfdjHlOmvHz_pOc2HvOJs1-Bpwn3AW2qXns642soudjrkkJ-TJ4OdMr54qGfky-X764uP1dXnD58uzq8qL1S3lp1R865vuZNODZ5p7ZC1QreNEL10XYeuk1oiausHj9o5L2QRSAnWIhfijLw59i0XfNswr2YO2eM02QXjlg1vpeJtK0AX9PU_6Bi3VPYtlIQGQIKGQokj5VPMOeFgblKYbToYBuY-DjOa33GY-zgMKFPiKKpXD703N2P_V_PH_wK8OwJYzCiWJZN9wOJuH1KJxPQx_HfAHSPWnhU</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Singh, Benjamin</creator><creator>Toohey, Kellie</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis</title><author>Singh, Benjamin ; Toohey, Kellie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-24e927d52b6b8fc199be15395433d6b77eb7696ee9acfce9bbc3627d660aae233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aerobic exercise</topic><topic>Bias</topic><topic>Bone</topic><topic>Bone Density</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer Survivors</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Endocrine therapy</topic><topic>Exercise</topic><topic>Exercise intensity</topic><topic>Exercise oncology</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Fractures</topic><topic>Humans</topic><topic>Intervention</topic><topic>Meta-analysis</topic><topic>Neoplasm</topic><topic>Osteoporosis</topic><topic>Physical fitness</topic><topic>Prostate cancer</topic><topic>Quality of life</topic><topic>Resistance exercise</topic><topic>Software</topic><topic>Supervision</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Benjamin</creatorcontrib><creatorcontrib>Toohey, Kellie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Australia & New Zealand Database</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of science and medicine in sport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Benjamin</au><au>Toohey, Kellie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis</atitle><jtitle>Journal of science and medicine in sport</jtitle><addtitle>J Sci Med Sport</addtitle><date>2022-01</date><risdate>2022</risdate><volume>25</volume><issue>1</issue><spage>31</spage><epage>40</epage><pages>31-40</pages><issn>1440-2440</issn><eissn>1878-1861</eissn><abstract>To evaluate the effectiveness of exercise for improving bone-related outcomes among cancer survivors.
Systematic review and meta-analysis.
An electronic search using the following databases: SPORTDiscus, Science Direct, CINAHL, MEDLINE, Cochrane, Pubmed, Ebscohost, ProQuest Nursing and Allied Health Source.
Randomised, controlled, exercise trials involving cancer survivors were eligible. Effect data on bone mineral content (BMC) and density (BMD) outcomes were extracted. Risk of bias was assessed using the Physiotherapy Evidence Database tool. Standardised mean differences (SMD) were calculated to compare differences between exercise and usual care. Subgroup analyses were conducted to assess whether effect differed by exercise mode, intervention length, supervision, treatment, cancer type and risk of bias.
Twenty-six trials were included, with intervention durations ranging between 12 weeks and 2 years. Most trials involved breast cancer (n = 13, 50%), and most interventions were supervised (n = 18, 69%) and evaluated mixed-mode (i.e., combined aerobic and resistance) exercise (n = 13, 50%). Significant effects in favour of exercise (aerobic, resistance, mixed-mode and other exercise) were observed for whole body BMD, hip BMD, trochanter BMD and femoral neck BMD (SMD range: 0.19–0.39, all p < 0.05) compared to usual care.
Participation in various modes (aerobic, resistance, mixed-mode and other) of supervised and unsupervised exercise is associated with improvements in BMD. The present results provide evidence for clinicians and other health care professionals (e.g., exercise physiologists and physiotherapists) to recommend exercise for cancer survivors to prevent bone loss during and following treatment.</abstract><cop>Australia</cop><pub>Elsevier Ltd</pub><pmid>34465518</pmid><doi>10.1016/j.jsams.2021.08.008</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1440-2440 |
| ispartof | Journal of science and medicine in sport, 2022-01, Vol.25 (1), p.31-40 |
| issn | 1440-2440 1878-1861 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2568255309 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Aerobic exercise Bias Bone Bone Density Breast cancer Breast Neoplasms - therapy Cancer Survivors Cancer therapies Chemotherapy Endocrine therapy Exercise Exercise intensity Exercise oncology Exercise Therapy Female Fractures Humans Intervention Meta-analysis Neoplasm Osteoporosis Physical fitness Prostate cancer Quality of life Resistance exercise Software Supervision Systematic review |
| title | The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis |
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