Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression

Summary Background Irritable bowel syndrome (IBS) patients often experience meal‐associated symptoms. However, the underlying mechanisms are unclear. Aim To determine small intestinal mechanisms of lipid‐induced symptoms and rectal hypersensitivity in IBS Methods We recruited 26 IBS patients (12 IBS...

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Published in:Alimentary pharmacology & therapeutics 2021-11, Vol.54 (9), p.1179-1192
Main Authors: Grover, Madhusudan, Berumen, Antonio, Peters, Stephanie, Wei, Ting, Breen‐Lyles, Margaret, Harmsen, William S., Busciglio, Irene, Burton, Duane, Vazquez Roque, Maria, DeVault, Kenneth R., Camilleri, Michael, Wallace, Michael, Dasari, Surendra, Neumann, Helmut, Houghton, Lesley A.
Format: Article
Language:English
Subjects:
Biopsy
Capsaicin receptors
Endoscopy
Hypersensitivity
Irritable bowel syndrome
Lipids
Mucosa
Nausea
Pain
Permeability
Rectum
Small intestine
Transient receptor potential proteins
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Summary:Summary Background Irritable bowel syndrome (IBS) patients often experience meal‐associated symptoms. However, the underlying mechanisms are unclear. Aim To determine small intestinal mechanisms of lipid‐induced symptoms and rectal hypersensitivity in IBS Methods We recruited 26 IBS patients (12 IBS‐C, 14 IBS‐D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion assay. Rectal sensitivity was assessed using a barostat before and after small bowel lipid infusion; symptoms were assessed throughout. Next, an extended upper endoscopy with probe‐based confocal laser endomicroscopy (pCLE) was performed with changes induced by lipids. Duodenal and jejunal mucosal biopsies were obtained for transcriptomics. Results Following lipid infusion, a higher proportion of HV than IBS patients reported no pain, no nausea, no fullness and no urgency (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.16591