Computerized Working Memory Training for Children With Neurofibromatosis Type 1 (NF1): A Pilot Study

• Published in: Journal of child neurology 2021-10, Vol.36 (12), p.1078-1085
• Main Authors: Hardy, Kristina K., Berger, Carly, Griffin, Danielle, Walsh, Karin S., Sharkey, Christina M., Weisman, Hannah, Gioia, Anthony, Packer, Roger J., Acosta, Maria T.
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Computer-Assisted Instruction - methods; Executive Function; Feasibility Studies; Female; Humans; Male; Memory, Short-Term - physiology; Neurofibromatosis 1 - physiopathology; Neurofibromatosis 1 - therapy; Neuropsychological Tests; Pilot Projects; Therapy, Computer-Assisted - methods; Treatment Outcome
• ISSN: 0883-0738; 1708-8283
• DOI: 10.1177/08830738211038083

Introduction: The present study aimed to evaluate the feasibility and efficacy of CogmedRM, a computerized, home-based working memory (WM) training program, in children with NF1. Method: A pre-post design was used to evaluate changes in performance-based measures of attention and WM, and parent-completed ratings of executive functioning. Children meeting eligibility criteria completed CogmedRM over 9 weeks. Primary outcomes included compliance statistics and change in attention and WM scores. Results: Thirty-one children (52% male; M age = 10.97 ± 2.51), aged 8-15, were screened for participation; 27 children (87%) evidenced WM difficulties and participated in CogmedRM training. On average, participants completed 19.7 out of 25 prescribed sessions, with an adherence rate of 69%. Participants demonstrated improvements in short-term memory, attention, and executive functioning (all Ps < .05). Conclusion: Results suggest that computerized, home-based WM training programs may be both feasible and efficacious for children with NF1 and cognitive deficits.