PDIA3: Structure, functions and its potential role in viral infections

• Published in: Biomedicine & pharmacotherapy 2021-11, Vol.143, p.112110-112110, Article 112110
• Main Authors: Mahmood, Faisal, Xu, Ruixian, Awan, Maher Un Nisa, Song, Yuzhu, Han, Qinqin, Xia, Xueshan, Zhang, Jinyang
• Format: Article
• Language: English
• Subjects: 16f16; Animals; Antiviral Agents - therapeutic use; Disulphide bonds; Endoplasmic reticulum stress; Enzyme Inhibitors - therapeutic use; Host-Pathogen Interactions; Humans; Misfolded proteins; Oxidoreduction; Protein Disulfide-Isomerases - antagonists & inhibitors; Protein Disulfide-Isomerases - metabolism; Protein disulphide isomerase; Viral infection; Virus Diseases - drug therapy; Virus Diseases - enzymology; Virus Diseases - virology; Virus Internalization; Virus Replication; Viruses - growth & development; Viruses - pathogenicity
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.112110

The catalysis of disulphide (SS) bonds is the most important characteristic of protein disulphide isomerase (PDI) family. Catalysis occurs in the endoplasmic reticulum, which contains many proteins, most of which are secretory in nature and that have at least one s-s bond. Protein disulphide isomerase A3 (PDIA3) is a member of the PDI family that acts as a chaperone. PDIA3 is highly expressed in response to cellular stress, and also intercept the apoptotic cellular death related to endoplasmic reticulum (ER) stress, and protein misfolding. PDIA3 expression is elevated in almost 70% of cancers and its expression has been linked with overall low cell invasiveness, survival and metastasis. Viral diseases present a significant public health threat. The presence of PDIA3 on the cell surface helps different viruses to enter the cells and also helps in replication. Therefore, inhibitors of PDIA3 have great potential to interfere with viral infections. In this review, we summarize what is known about the basic structure, functions and role of PDIA3 in viral infections. The review will inspire studies of pathogenic mechanisms and drug targeting to counter viral diseases. [Display omitted] •Protein disulphide isomerases are chaperones which functions according to redox potential of the substrate.•PDIA3 belongs to PDI family which comprises of 21 members.•PDIA3 has potential role in entry of virus and in viral replication.•16F16 down regulates PDIA3 activity, making it a great interest as potential antiviral target.