Unusual Nanofractal Microparticles for Rapid Protein Capture and Release

Ion exchange porous microparticles are widely used for protein separation, but their totally porous structure often leads to slow diffusion rate and long separation time. Here unusual nanofractal microparticles synthesized by a strategy of electrostatic interaction regulated emulsion interfacial pol...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-09, Vol.17 (36), p.e2102802-n/a
Main Authors: Song, Yongyang, Dong, Xuefang, Shang, Danyi, Zhang, Xiaofei, Li, Xiuling, Liang, Xinmiao, Wang, Shutao
Format: Article
Language:English
Subjects:
Diffusion rate
electrostatic interaction
emulsion interfacial polymerization
Emulsion polymerization
Ion exchange
Microparticles
nanofractal microparticles
Nanotechnology
protein capture and release
Proteins
Separation
Three dimensional models
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Summary:Ion exchange porous microparticles are widely used for protein separation, but their totally porous structure often leads to slow diffusion rate and long separation time. Here unusual nanofractal microparticles synthesized by a strategy of electrostatic interaction regulated emulsion interfacial polymerization are demonstrated that exhibit excellent capability of rapid protein capture, release, and separation. The growth of nanostructures at nanofractal microparticle surface can be controlled by changing electrostatic repulsion between ion groups from weak to strong. The nanofractal microparticles provide a 3D contact model between ion groups and proteins, enable fast protein diffusion rate at initial capture and release stage, and realize rapid and efficient separation of similarly sized proteins as a proof of concept, superior to porous microparticles. This strategy offers an effective and general way for the synthesis of microparticles towards rapid and efficient separation in various fields of biomedicine, environment, and food. Nanofractal microparticles, synthesized by electrostatic interaction regulated emulsion interfacial polymerization, can separate similarly sized proteins rapidly and efficiently. The growth of nanostructures at nanofractal microparticle surface can be controlled by changing electrostatic repulsion from weak to strong. They provide a 3D contact model between ion groups and proteins, enable fast protein capture, release, and separation, superior to porous microparticles.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202102802