Tessier 3 and 4 Clefts and Choanal Atresia: An Unusual Association?

Introduction Craniofacial clefts are rare congenital anomalies that might involve both soft tissue and skeletal components. The association of Tessier cleft number 3 and 4 with choanal atresia appears to be unusual and only few clinical cases have been reported in published literature. Objectives Re...

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Bibliographic Details
Published in:The Cleft palate-craniofacial journal 2022-10, Vol.59 (10), p.1228-1232
Main Authors: Tonello, Cristiano, Martins, Danilo Augusto Nery dos Passos, Baptista, Marco Antônio Ferraz de Barros, Mondelli, Felipe, Kokitsu Nakata, Nancy Mizue, Feitosa, Leonardo Bezerra, Alonso, Nivaldo
Format: Article
Language:English
Subjects:
Birth defects
Literature reviews
Patients
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Summary:Introduction Craniofacial clefts are rare congenital anomalies that might involve both soft tissue and skeletal components. The association of Tessier cleft number 3 and 4 with choanal atresia appears to be unusual and only few clinical cases have been reported in published literature. Objectives Report a series of 13 cases of choanal atresia in patients with Tessier numbers 3 or 4 clefts and the literature review on this topic. Methods A literature review was undertaken via PUBMED database before April 2020 addressing the association between Tessier numbers 3 or 4 clefts and choanal atresia. Retrospective chart review of patients diagnosed with both comorbidities at a tertiary hospital expertised in craniofacial anomalies. Results Literature review yielded 10 studies describing the relationship between choanal atresia and Tessier 3 and 4 facial clefts. We identified 98 patients diagnosed with medial oro-ocular facial clefts (Tessier 3 and 4) and 119 with choanal atresia at our institution over a 20 years time period. Altogether, 13 individuals were diagnosed with both malformations, 3 patients with number 3 cleft, and 10 patients with number 4 cleft. It represents 13.26% of the cases. Conclusion This study highlights the features of Tessier 3 and 4 facial clefts associated with choanal atresia. Although the publications regarding this association are very scarce, the authors present the largest series of cases of Tessier number 3 and 4 clefts with choanal atresia showing that association between these conditions could be not so unusual.
ISSN:1055-6656
1545-1569
DOI:10.1177/10556656211042172