A quadruple recombination event discovered in hepatitis E virus

Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but recombination in HEV has rarely been reported. In the present study, phylogenetic and recombination analysis was performed on 557 complete HEV genome sequences from the GenBank database. A potentially significant quadruple...

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Bibliographic Details
Published in:Archives of virology 2021-12, Vol.166 (12), p.3405-3408
Main Authors: Shen, Hao, Liu, Shuning, Ding, Min, Gu, Haixia, Chang, Ming, Li, Yanshuang, Wang, Hua, Bai, Xingwen, Shen, Hongxing
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Breakpoints
Brief Report
Genomes
Genotype
Genotype & phenotype
Genotypes
Hepatitis
Hepatitis E - veterinary
Hepatitis E virus - genetics
Infectious Diseases
Medical Microbiology
Phylogenetics
Phylogeny
Recombination
Recombination, Genetic
Strains (organisms)
Swine
Swine Diseases
Virology
Viruses
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Summary:Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but recombination in HEV has rarely been reported. In the present study, phylogenetic and recombination analysis was performed on 557 complete HEV genome sequences from the GenBank database. A potentially significant quadruple recombination event was identified by recombination detection analysis. The recombinant progeny virus, HEV_32_Manchester_301214, was produced by inter-genotype recombination between the major parent HEPAC-44 and the minor parent HE-JA15-1335. HEV_32_Manchester_301214 and HEPAC-44 belong to genotype 3, while HE-JA15-1335 belongs to genotype 1, and these three strains were all isolated from humans. Three breakpoints of the four recombination events occurred in the ORF2 region, while another occurred in the ORF1 region. This quadruple recombination event was confirmed by phylogenetic analysis. The genotype, host, and recombination regions of the three strains were analyzed, and the analysis results provide valuable information for future research on HEV diversity.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-021-05251-3