Clinical relevance of circulating activin A and follistatin in small cell lung cancer

•ActA and FST are significantly elevated in the plasma of SCLC patients.•High plasma ActA levels correlate with extensive-stage SCLC.•Elevated ActA concentration is an independent negative prognosticator in SCLC. Circulating levels of activin A (ActA) and follistatin (FST) have been investigated in...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2021-11, Vol.161, p.128-135
Main Authors: Barany, Nandor, Rozsas, Anita, Megyesfalvi, Zsolt, Grusch, Michael, Hegedus, Balazs, Lang, Christian, Boettiger, Kristiina, Schwendenwein, Anna, Tisza, Anna, Renyi-Vamos, Ferenc, Schelch, Karin, Hoetzenecker, Konrad, Hoda, Mir Alireza, Paku, Sandor, Laszlo, Viktoria, Dome, Balazs
Format: Article
Language:English
Subjects:
Activin A
Activins - metabolism
Biomarker
Follistatin
Follistatin - blood
Humans
Lung Neoplasms - diagnosis
Prognostic factor
Small cell lung cancer
Small Cell Lung Carcinoma
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Summary:•ActA and FST are significantly elevated in the plasma of SCLC patients.•High plasma ActA levels correlate with extensive-stage SCLC.•Elevated ActA concentration is an independent negative prognosticator in SCLC. Circulating levels of activin A (ActA) and follistatin (FST) have been investigated in various disorders including malignancies. However, to date, their diagnostic and prognostic relevance is largely unknown in small cell lung cancer (SCLC). Our aim was to evaluate circulating ActA and FST levels as potential biomarkers in this devastating disease. Seventy-nine Caucasian SCLC patients and 67 age- and sex-matched healthy volunteers were included in this study. Circulating ActA and FST concentrations were measured by ELISA and correlated with clinicopathological parameters and long-term outcomes. Plasma ActA and FST concentrations were significantly elevated in SCLC patients when compared to healthy volunteers (p 
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2021.09.008