Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study

Abstract Background Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of atrial fibrillation (AF) in several patient cohorts. The purpose of this study was to investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can be used t...

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Published in:European heart journal cardiovascular imaging 2021-12, Vol.23 (1), p.52-60
Main Authors: Hauser, Raphael, Nielsen, Anne Bjerg, Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Duus, Lisa Steen, Johansen, Niklas Dyrby, Sengeløv, Morten, Marott, Jacob Louis, Jensen, Gorm, Schnohr, Peter, Søgaard, Peter, Møgelvang, Rasmus, Biering-Sørensen, Tor
Format: Article
Language:English
Subjects:
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - epidemiology
Heart Atria - diagnostic imaging
Humans
Longitudinal Studies
Prospective Studies
Risk Assessment
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Summary:Abstract Background Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of atrial fibrillation (AF) in several patient cohorts. The purpose of this study was to investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can be used to predict the development of AF in the general population. Methods and results This prospective longitudinal study included 4466 participants from the fifth Copenhagen City Heart Study. All participants underwent a health examination, including echocardiographic measurements of LA strain. Participants with prevalent AF at baseline were excluded. The primary endpoint was incident AF. During a median follow-up period of 5.3 years, 154 (4.3%) participants developed AF. In univariable analysis, peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase were significantly associated with the development of AF. PALS [hazard ratio (HR) 1.05, 95% confidence interval (CI) (1.03–1.07), P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeab202