Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine

• Published in: Applied microbiology and biotechnology 2021-11, Vol.105 (21-22), p.8441-8456
• Main Authors: Tang, Shanlong, Zhang, Shunfen, Zhong, Ruqing, Su, Dan, Xia, Bing, Liu, Lei, Chen, Liang, Zhang, Hongfu
• Format: Article
• Language: English
• Subjects: Acid production; Antibacterial agents; Antibiotics; Applied Microbial and Cell Physiology; Bacteria; Biomedical and Life Sciences; Biotechnology; Body weight; Coliforms; Digestive system; Disruption; Dosage and administration; Drug therapy; Dysbacteriosis; Escherichia; Exposure; Fatty acids; Gastrointestinal tract; Hogs; Homeostasis; Immunoregulation; Intestinal microflora; Lactobacillus; Life Sciences; Lincomycin; Microbial Genetics and Genomics; Microbiology; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Pathogens; Patient outcomes; Physiological aspects; Probiotics; Relative abundance; Shigella; Swine
• ISSN: 0175-7598; 1432-0614
• DOI: 10.1007/s00253-021-11627-x

Increasing evidence suggests that antibiotic administration causes gut injury, negatively affecting nutrient digestion, immune regulation, and colonization resistance against pathogens due to the disruption of gut microbiota. However, the time-course effects of therapeutic antibiotics on alterations of gut microbes and short-chain fatty acids (SCFAs) in young swine are still unknown. In this study, twenty piglets were assigned into two groups and fed commercial diets with or without lincomycin in the first week for a 28-day trial period. Results showed that 1-week lincomycin exposure (LE) did reduce the body weight on day 14 ( p  = 0.0450) and 28 ( p  = 0.0362). The alpha-diversity notably reduced after 1-week LE, and then gradually raised and reached the control group level in the second week on cessation of LE, indicated by the variation of Sobs, Chao, Shannon, and ACE index ( p   3 or p