Incidence and survival for childhood central nervous system tumours in Australia, 1983–2016

Purpose To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. Methods National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced...

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Bibliographic Details
Published in:Journal of neuro-oncology 2021-11, Vol.155 (2), p.203-213
Main Authors: Youlden, Danny R., Henshaw, Chloe, Gottardo, Nicholas G., Hassall, Timothy, Aitken, Joanne F.
Format: Article
Language:English
Subjects:
Adolescent
Astrocytoma
Astrocytoma - epidemiology
Astrocytoma - mortality
Astrocytoma - pathology
Australia - epidemiology
Brain cancer
Central nervous system
Central Nervous System Neoplasms - epidemiology
Central Nervous System Neoplasms - mortality
Central Nervous System Neoplasms - pathology
Child
Childhood
Children
Clinical Study
Cohort Studies
Humans
Incidence
Infant
Medicine
Medicine & Public Health
Neoplasm Grading
Nervous system
Neurology
Oncology
Registries
Survival
Survival Analysis
Trends
Tumors
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Summary:Purpose To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. Methods National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. Relative survival was calculated using the cohort method, with changes in survival over time by cancer type and tumour grade assessed by multivariable flexible parametric survival modelling. Results The study cohort included 4914 patients, with astrocytoma (n = 2181, 44%) and embryonal tumours (n = 931, 19%) the most common diagnostic subgroups. Almost half (n = 2181, 44%) of all tumours were classified as high grade (III or IV). Incidence rates increased by 29% between 1983 and 2016, with high grade tumours rising by an annual average of + 1.1% (95% CI =  + 0.7%, + 1.5%, p 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-021-03869-6