A Single-Center Study of Adherence to Breast Cancer Screening Mammography Guidelines by Transgender and Non-Binary Patients

• Published in: Annals of surgical oncology 2022-03, Vol.29 (3), p.1707-1717
• Main Authors: Luehmann, Natalie, Ascha, Mona, Chwa, Emily, Hackenberger, Paige, Termanini, Kareem, Benning, Christopher, Sama, Danny, Felt, Dylan, Beach, Lauren B., Gupta, Dipti, Kulkarni, Swati A., Jordan, Sumanas W.
• Format: Article
• Language: English
• Subjects: Birth; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Oncology; Cancer screening; Early Detection of Cancer; Endocrine therapy; Female; Humans; Male; Mammography; Mass Screening; Medical screening; Medicine; Medicine & Public Health; Middle Aged; Non-binary gender; Oncology; Patients; Population studies; Risk factors; Surgery; Surgical Oncology; Transgender Persons
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-021-10932-z

Background Adherence to screening guidelines among transgender and non-binary (TGNB) populations is not well studied. This study examines breast cancer screening patterns among TGNB patients at an urban academic medical center. Methods Demographic information, risk factors, and screening mammography were collected. Mammography rates were calculated in populations of interest according to national guidelines, and mammogram person-years were also calculated. Univariate and multivariate logistic regression was performed. Results Overall, 253 patients were analyzed: 193 transgender women and non-binary people designated male at birth (TGNB DMAB) and 60 transgender men and non-binary people designated female at birth (TGNB DFAB). The median (interquartile range) age was 53.2 years (42.3–62.6). Most patients had no family history of breast cancer ( n  = 163, 64.4%) and were on hormone therapy ( n  = 191, 75.5%). Most patients where White ( n  = 164, 64.8%), employed ( n  = 113, 44.7%), and had public insurance ( n  = 128, 50.6%). TGNB DFAB breast screening rates were low, ranging from 2.0 to 50.0%, as were TGNB DMAB screening rates, ranging from 7.1 to 47.6%. The screening rates among the TGNB DFAB and TGNB DMAB groups did not significantly differ from one another. Among TGNB DFAB patients, univariate analyses showed no significant predictors for mammography. Among TGNB DMAB patients, not being on hormone therapy resulted in fewer odds of undergoing mammography. There were no significant findings on multivariate analyses. Conclusion Mammography rates in the TGNB population are lower than institutional and national rates for cisgender patients, which are 77.3% and 66.7–78.4%, respectively. Stage of transition, organs present, hormone therapy, and risk factors should be considered to guide screening.