Factors Affecting Time to Surgery in Breast Cancer Patients

• Published in: The American surgeon 2022-04, Vol.88 (4), p.648-652
• Main Authors: Chagpar, Anees B., Howard-McNatt, Marissa, Chiba, Akiko, Levine, Edward A., Gass, Jennifer S., Gallagher, Kristalyn, Lum, Sharon, Martinez, Ricardo, Willis, Allric I., Fenton, Andrew, Solomon, Naveenraj L., Senthil, Magi, Edmonson, David, Namm, Jukes P., Walters, Laura, Brown, Eric, Murray, Mary, Ollila, David, Dupont, Elisabeth, Garcia-Cantu, Carlos
• Format: Article
• Language: English
• Subjects: Biopsy; Breast cancer; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cancer therapies; Clinical trials; Ethnicity; Female; Hispanic people; Hospitals; Humans; Lumpectomy; Lymphatic system; Magnetic resonance imaging; Mammography; Mastectomy; Minority & ethnic groups; Mortality; Multivariate analysis; Neoadjuvant Therapy; Patients; Retrospective Studies; Surgeons; Surgery; Time-to-Treatment; Tumors; Ultrasonic imaging
• ISSN: 0003-1348; 1555-9823
• DOI: 10.1177/00031348211054714

Background We sought to determine factors affecting time to surgery (TTS) to identify potential modifiable factors to improve timeliness of care. Methods Patients with clinical stage 0-3 breast cancer undergoing partial mastectomy in 2 clinical trials, conducted in ten centers across the US, were analyzed. No preoperative workup was mandated by the study; those receiving neoadjuvant therapy were excluded. Results The median TTS among the 583 patients in this cohort was 34 days (range: 1-289). Patient age, race, tumor palpability, and genomic subtype did not influence timeliness of care defined as TTS ≤30 days. Hispanic patients less likely to have a TTS ≤30 days (P = .001). There was significant variation in TTS by surgeon (P < .001); those practicing in an academic center more likely to have TTS ≤30 days than those in a community setting (55.1% vs 19.3%, P < .001). Patients who had a preoperative ultrasound had a similar TTS to those who did not (TTS ≤30 days 41.9% vs 51.9%, respectively, P = .109), but those who had a preoperative MRI had a significantly increased TTS (TTS ≤30 days 25.0% vs 50.9%, P < .001). On multivariate analysis, patient ethnicity was no longer significantly associated with TTS ≤30 (P = .150). Rather, use of MRI (OR: .438; 95% CI: .287-.668, P < .001) and community practice type (OR: .324; 95% CI: .194-.541, P < .001) remained independent predictors of lower likelihood of TTS ≤30 days. Conclusions Preoperative MRI significantly increases time to surgery; surgeons should consider this in deciding on its use.