Effects of sleep interventions on cancer-related fatigue and quality of life in cancer patients: a systematic review and meta-analysis

Background Nondrug treatments are potentially beneficial for cancer patients. However, the effect of sleep on cancer-related fatigue (CRF) and quality of life (QOL) in cancer patients remains unclear. We conducted a meta-analysis of randomized controlled trials to examine the efficacy of sleep in ca...

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Bibliographic Details
Published in:Supportive care in cancer 2022-04, Vol.30 (4), p.3043-3055
Main Authors: Dun, Liu, Xian-Yi, Wu, Si-Ting, Huang, Xin-Yuan, Yu
Format: Article
Language:English
Subjects:
Analysis
Behavior modification
Cancer
Cancer patients
Care and treatment
China
Fatigue
Fatigue - etiology
Fatigue - therapy
Humans
Medicine
Medicine & Public Health
Meta-analysis
Neoplasms - complications
Neoplasms - psychology
Neoplasms - therapy
Nursing
Nursing Research
Oncology
Pain Medicine
Physiological aspects
Quality of Life
Rehabilitation Medicine
Review Article
Sleep
Therapy
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Summary:Background Nondrug treatments are potentially beneficial for cancer patients. However, the effect of sleep on cancer-related fatigue (CRF) and quality of life (QOL) in cancer patients remains unclear. We conducted a meta-analysis of randomized controlled trials to examine the efficacy of sleep in cancer patients undergoing treatment. Methods The PubMed, Ovid, Embase, Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure databases were searched to identify suitable studies. Stata 15.0 software was used for statistical analyses. Sensitivity analyses were conducted. Fourteen studies (6 in English and 8 in Chinese) involving 1151 patients were included in the meta-analysis. Ten, five, and six studies that assessed the effects of sleep on CRF, QOL, and quality of sleep, respectively, in cancer patients undergoing treatment were identified. Results Sleep interventions significantly affected overall CRF (standardized mean difference ( SMD ) = −1.52, P < 0.01), overall QOL ( SMD = 1.20, P < 0.01), physical fatigue ( SMD = −0.66, P < 0.01), cognitive fatigue ( SMD = −0.38, P = 0.015), and physical function ( SMD = 0.64, P < 0.01). Comprehensive intervention measures focusing on sleep, sleep nondrug interventions, and interventions for ≥3 or
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-021-06563-5