Clinical analysis of the therapeutic effect of plasma exchange on hypertriglyceridemic acute pancreatitis: A retrospective study

Background The therapeutic effect of plasma exchange (PE) on hypertriglyceridemic acute pancreatitis (HTGAP) is unclear. Therefore, we aimed to explore this therapeutic effect. Study design and methods This study included 204 patients with HTGAP who underwent treatment at two provincial tertiary gra...

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Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-01, Vol.62 (1), p.72-81
Main Authors: Lin, Yongxu, Yu, Shufang, Wu, Xiaofan, Huang, Letong, Huang, Simei, Huang, Yongzhu, Ding, Jian, Li, Dan
Format: Article
Language:English
Subjects:
Acute Disease
Acute Kidney Injury - etiology
Acute Kidney Injury - therapy
acute pancreatitis
Apheresis
Complications
Data analysis
Dimers
D‐dimer
Failure
Health services
Humans
hypertriglyceridemia
Kidneys
Mortality
Multiple organ dysfunction syndrome
Multiple Organ Failure - etiology
Multiple Organ Failure - therapy
Pancreatitis
Pancreatitis - complications
Pancreatitis - therapy
Patients
plasma exchange
Plasma Exchange - adverse effects
Pregnancy complications
Renal failure
Retrospective Studies
Statistical analysis
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Summary:Background The therapeutic effect of plasma exchange (PE) on hypertriglyceridemic acute pancreatitis (HTGAP) is unclear. Therefore, we aimed to explore this therapeutic effect. Study design and methods This study included 204 patients with HTGAP who underwent treatment at two provincial tertiary grade A hospitals in Fujian Province from October 2012 to May 2021. Patients were divided into a conventional group and a PE group. The Student's t‐test and chi‐square test were used for data analysis. Results Among 204 patients, 56 and 148 were included in the PE and conventional groups, respectively. After propensity score matching (PSM), the PE and conventional groups each had 42 patients. There was no significant difference in age; sex; pregnancy; comorbidities; laboratory findings; incidences of complications, and multiple organ dysfunction syndrome (MODS); organ support treatment; surgical rate; mortality; and hospital stay between the groups (p > 0.05). The total expenses were significantly higher in the PE group than in the conventional group (p  0.05). All patients in the PE group and conventional group with acute renal failure had significantly higher D‐dimer levels than those without acute renal failure (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.16724