Women receive less targeted temperature management than men following out-of-hospital cardiac arrest due to early care limitations – A study from the CARES Investigators

Women experience worse neurological outcomes following out-of-hospital cardiac arrest (OHCA). It is unknown whether sex disparities exist in the use of targeted temperature management (TTM), a standard of care treatment to improve neurological outcomes. We performed a retrospective study of prospect...

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Bibliographic Details
Published in:Resuscitation 2021-12, Vol.169, p.97-104
Main Authors: Morris, Nicholas A., Mazzeffi, Michael, McArdle, Patrick, May, Teresa L., Burke, James F., Bradley, Steven M., Agarwal, Sachin, Badjatia, Neeraj, Perman, Sarah M.
Format: Article
Language:English
Subjects:
Cardiac arrest
Cardiopulmonary Resuscitation
Disparities
Female
Healthcare disparities
Heart arrest
Humans
Hypothermia, Induced
Induced hypothermia
Male
Odds Ratio
Out-of-Hospital Cardiac Arrest - therapy
Post cardiac arrest care
Registries
Retrospective Studies
Sex
Sex factors
Targeted temperature management
Therapeutic hypothermia
Therapeutics
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Summary:Women experience worse neurological outcomes following out-of-hospital cardiac arrest (OHCA). It is unknown whether sex disparities exist in the use of targeted temperature management (TTM), a standard of care treatment to improve neurological outcomes. We performed a retrospective study of prospectively collected patients who survived to hospital admission following OHCA from the Cardiac Arrest Registry to Enhance Survival from 2013 through 2019. We compared receipt of TTM by sex in a mixed-effects model adjusted for patient, arrest, neighborhood, and hospital factors, with the admitting hospital modeled as a random intercept. Among 123,419 patients, women had lower rates of shockable rhythms (24.4 % vs. 39.2%, P 
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2021.10.036