Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis

Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect...

Full description

Saved in:
Bibliographic Details
Published in:Pacing and clinical electrophysiology 2022-02, Vol.45 (2), p.212-218
Main Authors: Cheng, Yuda, Wang, Zhanqi, Li, Yujun, Qi, Jinlei, Liu, Jinyu
Format: Article
Language:English
Subjects:
biventricular pacing
Bundle-Branch Block - complications
Bundle-Branch Block - therapy
Cardiac Pacing, Artificial - methods
cardiac resynchronization therapy
Classification
Clinical trials
Congestive heart failure
Heart failure
Heart Failure - complications
Heart Failure - therapy
Humans
left bundle branch block
left bundle branch pacing
Meta-analysis
Patients
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923
cites cdi_FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923
container_end_page 218
container_issue 2
container_start_page 212
container_title Pacing and clinical electrophysiology
container_volume 45
creator Cheng, Yuda
Wang, Zhanqi
Li, Yujun
Qi, Jinlei
Liu, Jinyu
description Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. This study aim to explore the efficacy and safety of LBBP in heart failure patients with LBBB. Methods We searched PubMed, Cochrane Library, Web of science, and CNKI databases for studies about LBBP in heart failure patients with LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, B‐type natriuretic peptide (BNP) concentration, left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), pacing threshold and other related data were extracted and summarized. Results A total of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21–64.25, p 
doi_str_mv 10.1111/pace.14405
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2597484138</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2597484138</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923</originalsourceid><addsrcrecordid>eNp90ctq3DAUBmBRGprJtJs-QBF0UwKeStbFVnfDkBsMpIt2bY7l445S2Z5KdobpKo_QZ8yTRMmkXbRQbQ6I7_wc-Al5y9mCp_dxCxYXXEqmXpAZV5JlJVfmJZkxLousFKU5Jicx3jDGNJPqFTkWstBaKDMjP9fYjrSe-sYjrQP0dkNTnuu_UdfTDUIYaQvOTwHT_-iwHyPduXFD_b-LtR_s9090SeM-jtglbmnAW4c7Cn1DOxzh_u4X9OD30cXX5KgFH_HN85yTr-dnX1aX2fr64mq1XGdWqEJltdBGF7VuOOQyR2OsNUxYQMaNZiIvtWhqIYAjVxoNogBVSyxAtKUEk4s5-XDI3Ybhx4RxrDoXLXoPPQ5TrHJlCllKLspE3_9Fb4YppHuT0nmRl1wwk9TpQdkwxBiwrbbBdRD2FWfVYyPVYyPVUyMJv3uOnOoOmz_0dwUJ8APYOY_7_0RVn5ers0PoA_BDlwU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2627281309</pqid></control><display><type>article</type><title>Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><source>EBSCOhost SPORTDiscus - Ebooks</source><creator>Cheng, Yuda ; Wang, Zhanqi ; Li, Yujun ; Qi, Jinlei ; Liu, Jinyu</creator><creatorcontrib>Cheng, Yuda ; Wang, Zhanqi ; Li, Yujun ; Qi, Jinlei ; Liu, Jinyu</creatorcontrib><description>Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. This study aim to explore the efficacy and safety of LBBP in heart failure patients with LBBB. Methods We searched PubMed, Cochrane Library, Web of science, and CNKI databases for studies about LBBP in heart failure patients with LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, B‐type natriuretic peptide (BNP) concentration, left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), pacing threshold and other related data were extracted and summarized. Results A total of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21–64.25, p &lt; .01). Echocardiographic parameters including LVEF and LVEDD significantly improved (both with p &lt; .01). Clinical outcomes including NYHA classification and BNP dramatically reduced (both with p &lt; .01). Compared with biventricular pacing (BVP), LBBP could further improve QRSd, LVEF, LVEDD, and NYHA classification (all with p &lt; .01). However, the pacing threshold at follow‐up was 0.06 V higher than that at baseline (p &lt; .01), and the incidence of complications was 2.4%. Conclusions LBBP is effective and safe in heart failure patients with LBBB, whether it is better than BVP needs to be verified by randomized controlled trials.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/pace.14405</identifier><identifier>PMID: 34766359</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>biventricular pacing ; Bundle-Branch Block - complications ; Bundle-Branch Block - therapy ; Cardiac Pacing, Artificial - methods ; cardiac resynchronization therapy ; Classification ; Clinical trials ; Congestive heart failure ; Heart failure ; Heart Failure - complications ; Heart Failure - therapy ; Humans ; left bundle branch block ; left bundle branch pacing ; Meta-analysis ; Patients ; Ventricle</subject><ispartof>Pacing and clinical electrophysiology, 2022-02, Vol.45 (2), p.212-218</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><rights>2022 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923</citedby><cites>FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923</cites><orcidid>0000-0002-3251-9507 ; 0000-0003-4937-2123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34766359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Yuda</creatorcontrib><creatorcontrib>Wang, Zhanqi</creatorcontrib><creatorcontrib>Li, Yujun</creatorcontrib><creatorcontrib>Qi, Jinlei</creatorcontrib><creatorcontrib>Liu, Jinyu</creatorcontrib><title>Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. This study aim to explore the efficacy and safety of LBBP in heart failure patients with LBBB. Methods We searched PubMed, Cochrane Library, Web of science, and CNKI databases for studies about LBBP in heart failure patients with LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, B‐type natriuretic peptide (BNP) concentration, left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), pacing threshold and other related data were extracted and summarized. Results A total of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21–64.25, p &lt; .01). Echocardiographic parameters including LVEF and LVEDD significantly improved (both with p &lt; .01). Clinical outcomes including NYHA classification and BNP dramatically reduced (both with p &lt; .01). Compared with biventricular pacing (BVP), LBBP could further improve QRSd, LVEF, LVEDD, and NYHA classification (all with p &lt; .01). However, the pacing threshold at follow‐up was 0.06 V higher than that at baseline (p &lt; .01), and the incidence of complications was 2.4%. Conclusions LBBP is effective and safe in heart failure patients with LBBB, whether it is better than BVP needs to be verified by randomized controlled trials.</description><subject>biventricular pacing</subject><subject>Bundle-Branch Block - complications</subject><subject>Bundle-Branch Block - therapy</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>cardiac resynchronization therapy</subject><subject>Classification</subject><subject>Clinical trials</subject><subject>Congestive heart failure</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>left bundle branch block</subject><subject>left bundle branch pacing</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Ventricle</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp90ctq3DAUBmBRGprJtJs-QBF0UwKeStbFVnfDkBsMpIt2bY7l445S2Z5KdobpKo_QZ8yTRMmkXbRQbQ6I7_wc-Al5y9mCp_dxCxYXXEqmXpAZV5JlJVfmJZkxLousFKU5Jicx3jDGNJPqFTkWstBaKDMjP9fYjrSe-sYjrQP0dkNTnuu_UdfTDUIYaQvOTwHT_-iwHyPduXFD_b-LtR_s9090SeM-jtglbmnAW4c7Cn1DOxzh_u4X9OD30cXX5KgFH_HN85yTr-dnX1aX2fr64mq1XGdWqEJltdBGF7VuOOQyR2OsNUxYQMaNZiIvtWhqIYAjVxoNogBVSyxAtKUEk4s5-XDI3Ybhx4RxrDoXLXoPPQ5TrHJlCllKLspE3_9Fb4YppHuT0nmRl1wwk9TpQdkwxBiwrbbBdRD2FWfVYyPVYyPVUyMJv3uOnOoOmz_0dwUJ8APYOY_7_0RVn5ers0PoA_BDlwU</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Cheng, Yuda</creator><creator>Wang, Zhanqi</creator><creator>Li, Yujun</creator><creator>Qi, Jinlei</creator><creator>Liu, Jinyu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3251-9507</orcidid><orcidid>https://orcid.org/0000-0003-4937-2123</orcidid></search><sort><creationdate>202202</creationdate><title>Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis</title><author>Cheng, Yuda ; Wang, Zhanqi ; Li, Yujun ; Qi, Jinlei ; Liu, Jinyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>biventricular pacing</topic><topic>Bundle-Branch Block - complications</topic><topic>Bundle-Branch Block - therapy</topic><topic>Cardiac Pacing, Artificial - methods</topic><topic>cardiac resynchronization therapy</topic><topic>Classification</topic><topic>Clinical trials</topic><topic>Congestive heart failure</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>left bundle branch block</topic><topic>left bundle branch pacing</topic><topic>Meta-analysis</topic><topic>Patients</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Yuda</creatorcontrib><creatorcontrib>Wang, Zhanqi</creatorcontrib><creatorcontrib>Li, Yujun</creatorcontrib><creatorcontrib>Qi, Jinlei</creatorcontrib><creatorcontrib>Liu, Jinyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Yuda</au><au>Wang, Zhanqi</au><au>Li, Yujun</au><au>Qi, Jinlei</au><au>Liu, Jinyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>2022-02</date><risdate>2022</risdate><volume>45</volume><issue>2</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>Background The clinical benefit of cardiac resynchronization therapy (CRT) in heart failure patients with left bundle branch block (LBBB) has been demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. This study aim to explore the efficacy and safety of LBBP in heart failure patients with LBBB. Methods We searched PubMed, Cochrane Library, Web of science, and CNKI databases for studies about LBBP in heart failure patients with LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, B‐type natriuretic peptide (BNP) concentration, left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), pacing threshold and other related data were extracted and summarized. Results A total of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21–64.25, p &lt; .01). Echocardiographic parameters including LVEF and LVEDD significantly improved (both with p &lt; .01). Clinical outcomes including NYHA classification and BNP dramatically reduced (both with p &lt; .01). Compared with biventricular pacing (BVP), LBBP could further improve QRSd, LVEF, LVEDD, and NYHA classification (all with p &lt; .01). However, the pacing threshold at follow‐up was 0.06 V higher than that at baseline (p &lt; .01), and the incidence of complications was 2.4%. Conclusions LBBP is effective and safe in heart failure patients with LBBB, whether it is better than BVP needs to be verified by randomized controlled trials.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34766359</pmid><doi>10.1111/pace.14405</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3251-9507</orcidid><orcidid>https://orcid.org/0000-0003-4937-2123</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0147-8389
ispartof Pacing and clinical electrophysiology, 2022-02, Vol.45 (2), p.212-218
issn 0147-8389
1540-8159
language eng
recordid cdi_proquest_miscellaneous_2597484138
source Wiley-Blackwell Read & Publish Collection; EBSCOhost SPORTDiscus - Ebooks
subjects biventricular pacing
Bundle-Branch Block - complications
Bundle-Branch Block - therapy
Cardiac Pacing, Artificial - methods
cardiac resynchronization therapy
Classification
Clinical trials
Congestive heart failure
Heart failure
Heart Failure - complications
Heart Failure - therapy
Humans
left bundle branch block
left bundle branch pacing
Meta-analysis
Patients
Ventricle
title Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and meta‐analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A05%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Left%20bundle%20branch%20pacing%20in%20heart%20failure%20patients%20with%20left%20bundle%20branch%20block:%20A%20systematic%20review%20and%20meta%E2%80%90analysis&rft.jtitle=Pacing%20and%20clinical%20electrophysiology&rft.au=Cheng,%20Yuda&rft.date=2022-02&rft.volume=45&rft.issue=2&rft.spage=212&rft.epage=218&rft.pages=212-218&rft.issn=0147-8389&rft.eissn=1540-8159&rft_id=info:doi/10.1111/pace.14405&rft_dat=%3Cproquest_cross%3E2597484138%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3575-b36967b6d1a242e99cc903cae0196032863db33a1e156e9ee3a5b4e7a3f84a923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2627281309&rft_id=info:pmid/34766359&rfr_iscdi=true