microRNAs in newborns with low birth weight: relation to birth size and body composition

Background Children with low birth weight (LBW) have a higher risk of developing endocrine-metabolic disorders later in life. Deregulation of specific microRNAs (miRNAs) could underscore the programming of adult pathologies. We analyzed the miRNA expression pattern in both umbilical cord serum sampl...

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Bibliographic Details
Published in:Pediatric research 2022-09, Vol.92 (3), p.829-837
Main Authors: Garcia-Beltran, Cristina, Carreras-Badosa, Gemma, Bassols, Judit, Malpique, Rita, Plou, Cristina, de Zegher, Francis, López-Bermejo, Abel, Ibáñez, Lourdes
Format: Article
Language:English
Subjects:
Birth weight
Body composition
Clinical Research Article
Epigenetics
Medicine
Medicine & Public Health
Metabolic disorders
MicroRNAs
Pediatric Surgery
Pediatrics
Umbilical cord
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Summary:Background Children with low birth weight (LBW) have a higher risk of developing endocrine-metabolic disorders later in life. Deregulation of specific microRNAs (miRNAs) could underscore the programming of adult pathologies. We analyzed the miRNA expression pattern in both umbilical cord serum samples from LBW and appropriate-for-gestational-age (AGA) newborns and maternal serum samples in the 3rd trimester of gestation, and delineated the relationships with fetal growth, body composition, and markers of metabolic risk. Methods Serum samples of 12 selected mother–newborn pairs, including 6 LBW and 6 AGA newborns, were used for assessing miRNA profile by RNA-sequencing. The miRNAs with differential expression were validated in a larger cohort [49 maternal samples and 49 umbilical cord samples (24 LBW, 25 AGA)] by RT-qPCR. Anthropometric, endocrine-metabolic markers and body composition (by DXA) in infants were determined longitudinally over 12 months. Results LBW newborns presented reduced circulating concentrations of miR-191-3p ( P  = 0.015). miR-191-3p levels reliably differentiated LBW from AGA individuals (ROC AUC = 0.76) and were positively associated with anthropometric and body composition measures at birth and weight Z -score at 12 months ( P  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-021-01845-4