Graphical user interface for the haplotype frequency estimation software Hapl-o-Mat

Population-specific human leukocyte antigen (HLA) haplotype frequencies are an essential basis of advanced algorithms for donor selection in unrelated hematopoietic stem cell transplantation. In 2016, we introduced Hapl-o-Mat, a versatile tool for haplotype frequency estimation based on an expectati...

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Bibliographic Details
Published in:Human immunology 2022-02, Vol.83 (2), p.107-112
Main Authors: Solloch, Ute V., Schmidt, Alexander H., Sauter, Jürgen
Format: Article
Language:English
Subjects:
Gene Frequency
Haplotype frequencies
Haplotypes
HLA
HLA Antigens - genetics
HSCT
Humans
Software
Tissue Donors
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Summary:Population-specific human leukocyte antigen (HLA) haplotype frequencies are an essential basis of advanced algorithms for donor selection in unrelated hematopoietic stem cell transplantation. In 2016, we introduced Hapl-o-Mat, a versatile tool for haplotype frequency estimation based on an expectation-maximization algorithm (https://github.com/DKMS/hapl-o-Mat). Hapl-o-Mat is specifically tailored to the analysis of HLA genes and able to cope with the heterogeneous genotyping data usually found in donor registries. To make Hapl-o-Mat accessible to a wider range of users, we designed a graphical user interface module that considerably facilitates the interaction with the application (https://github.com/DKMS/hapl-o-Mat_GUI). We further provide a precompiled version of Hapl-o-Mat that can be used on Windows personal computers without dependency on additional software libraries (https://github.com/DKMS/hapl-o-Mat_WinBin). We are confident that these new, user-oriented features will encourage more researchers to apply Hapl-o-Mat to their data, thereby increasing knowledge and public availability of population-specific HLA haplotype frequencies.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2021.11.002