The effects of maternal hypertension on the early neonatal platelet count

Objective To examine the relationship between maternal hypertension and early neonatal platelet counts. Study design This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) ( n  = 22...

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Bibliographic Details
Published in:Journal of perinatology 2022-06, Vol.42 (6), p.796-802
Main Authors: Joslyn, Peter, Rosenbaum, Cornelius, Chapple, Andrew G., Heard, Asha, Velez, Maria, Barkemeyer, Brian
Format: Article
Language:English
Subjects:
631/136/232/2051/1339
692/499
692/699/1541
692/700/1720
Babies
Birth weight
Blood platelets
Blood pressure
Creatinine
Female
Gestational age
Health sciences
Humans
Hypertension
Infant
Infant, Newborn
Infant, Newborn, Diseases
Infants
Medicine
Medicine & Public Health
Mothers
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Platelet Count
Platelets
Pre-Eclampsia
Preeclampsia
Pregnancy
Regression analysis
Regression models
Retrospective Studies
Risk analysis
Risk factors
Small for gestational age
Statistical analysis
Thrombocytopenia
Thrombocytopenia - etiology
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Summary:Objective To examine the relationship between maternal hypertension and early neonatal platelet counts. Study design This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) ( n  = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models. Result There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68–2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13–4.30). Conclusion Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-021-01278-1