Palladium-Catalyzed Aminomethylative Oppolzer-Type Cyclization of Enynes: Access to Aminomethylated Benzofulvenes

A novel palladium-catalyzed Oppolzer-type cyclization reaction aided by the aminomethyl cyclopalladated complex has been developed, which provides rapid access to functionalized benzofulvenes with excellent stereoselectivity. The corresponding products can undergo Diels–Alder reaction with maleimide...

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Bibliographic Details
Published in:Organic letters 2021-12, Vol.23 (24), p.9510-9515
Main Authors: Huang, Renbin, Yu, Bangkui, Li, Renren, Huang, Hanmin
Format: Article
Language:English
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Summary:A novel palladium-catalyzed Oppolzer-type cyclization reaction aided by the aminomethyl cyclopalladated complex has been developed, which provides rapid access to functionalized benzofulvenes with excellent stereoselectivity. The corresponding products can undergo Diels–Alder reaction with maleimides, providing a series of complex polycyclic compounds with excellent regio- and stereoselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c03720