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Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance
Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or i...
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Published in: | Molecular and cellular biochemistry 2022-02, Vol.477 (2), p.593-604 |
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description | Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment. |
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During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04308-w</identifier><identifier>PMID: 34854022</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Apoptosis ; Autophagosomes - genetics ; Autophagosomes - metabolism ; Autophagy ; Autophagy-Related Proteins - genetics ; Autophagy-Related Proteins - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Brain tumors ; Cardiology ; Cell death ; Cellular stress response ; Development and progression ; Glioma ; Glioma - genetics ; Glioma - metabolism ; Glioma - therapy ; Gliomas ; Homeostasis ; Humans ; Isoforms ; Life Sciences ; Lysosomes ; Macromolecules ; Medical Biochemistry ; Necroptosis ; Neoplasm Proteins - metabolism ; Nutrients ; Oncology ; Organelles ; Phagosomes ; Proteins ; Tumor cells</subject><ispartof>Molecular and cellular biochemistry, 2022-02, Vol.477 (2), p.593-604</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-70cd52d0f24e8a7e4e56deeab1a4120a809bc4618269a2cf654cae257ef0fbc93</citedby><cites>FETCH-LOGICAL-c442t-70cd52d0f24e8a7e4e56deeab1a4120a809bc4618269a2cf654cae257ef0fbc93</cites><orcidid>0000-0002-7621-9477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34854022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belyaeva, Elizaveta</creatorcontrib><creatorcontrib>Kharwar, Rajesh Kumar</creatorcontrib><creatorcontrib>Ulasov, Ilya V.</creatorcontrib><creatorcontrib>Karlina, Irina</creatorcontrib><creatorcontrib>Timashev, Petr</creatorcontrib><creatorcontrib>Mohammadinejad, Reza</creatorcontrib><creatorcontrib>Acharya, Arbind</creatorcontrib><title>Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. 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This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Autophagosomes - genetics</subject><subject>Autophagosomes - metabolism</subject><subject>Autophagy</subject><subject>Autophagy-Related Proteins - genetics</subject><subject>Autophagy-Related Proteins - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Brain tumors</subject><subject>Cardiology</subject><subject>Cell death</subject><subject>Cellular stress response</subject><subject>Development and progression</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glioma - therapy</subject><subject>Gliomas</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Isoforms</subject><subject>Life Sciences</subject><subject>Lysosomes</subject><subject>Macromolecules</subject><subject>Medical Biochemistry</subject><subject>Necroptosis</subject><subject>Neoplasm Proteins - 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subjects | Antimitotic agents Antineoplastic agents Apoptosis Autophagosomes - genetics Autophagosomes - metabolism Autophagy Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Biochemistry Biomedical and Life Sciences Brain tumors Cardiology Cell death Cellular stress response Development and progression Glioma Glioma - genetics Glioma - metabolism Glioma - therapy Gliomas Homeostasis Humans Isoforms Life Sciences Lysosomes Macromolecules Medical Biochemistry Necroptosis Neoplasm Proteins - metabolism Nutrients Oncology Organelles Phagosomes Proteins Tumor cells |
title | Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance |
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