Discovery of novel phenaleno isoquinolinium-based fluorescence imaging agents for sentinel lymph node mapping

Fluorescence imaging agents have recently received huge attention due to their important role in disease diagnostics. However, the intrinsic problems of these probes, such as complex synthetic routes and high molecular weight, remain challenging. Here, we developed novel phenaleno isoquinolinium-bas...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-12, Vol.9 (48), p.9946-995
Main Authors: Han, Ye Ri, Lee, Da-Sol, Lee, Sang Bong, Jeon, Hui-Jeon, Lee, Sijoon, Sung, Soo-Eun, Lee, Chang-Hee, Cho, Sung Jin, Kim, Kil Soo, Kim, Dong-Su, Jeon, Yong Hyun
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials - administration & dosage
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Cell Line
Cell proliferation
Chemical compounds
Cricetulus
Drug Discovery
Fluorescence
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorophores
Injections, Intravenous
Isoquinolines - administration & dosage
Isoquinolines - chemistry
Lymph nodes
Materials Testing
Medical imaging
Mice
Molecular Structure
Molecular weight
Optical Imaging
Phenalenes - administration & dosage
Phenalenes - chemistry
Salts
Sentinel Lymph Node - diagnostic imaging
Toxicity
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Summary:Fluorescence imaging agents have recently received huge attention due to their important role in disease diagnostics. However, the intrinsic problems of these probes, such as complex synthetic routes and high molecular weight, remain challenging. Here, we developed novel phenaleno isoquinolinium-based fluorescent agents, Medical Fluorophores 37-41 (MF37-41) , applicable to the quantitative and sensitive detection of sentinel lymph nodes (SLNs). These imaging agents showed no adverse effects on the proliferation of immune and normal cells and did not induce in vivo toxicity. In vivo fluorescence lifetime imaging demonstrated the accumulation of phenaleno isoquinolinium salts in the SLNs of nude mice within 15 min postinjection, consistent with our biodistribution findings. These results suggest that phenaleno isoquinolinium salts are feasible fluorescence imaging agents that can be used as potential lymphatic tracers. We reported on the development of novel fluorescent agents (called Medical Fluorophores) and their usefulness for in vivo detection in the diagnosis of sentinel lymph nodes.
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb02146j