Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19

COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19 patients, we found extensive accumulation of the tryptophan degradation products 3‐hydroxy‐anthranilic acid and quinolinic acid in the lungs, heart, and brain. This was not related to the expression of the try...

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Published in:	The Journal of pathology 2022-03, Vol.256 (3), p.256-261
Main Authors:	Guo, Lihui, Schurink, Bernadette, Roos, Eva, Nossent, Esther J, Duitman, Jan Willem, Vlaar, Alexander PJ, Valk, Paul, Vaz, Frédéric M, Yeh, Syun‐Ru, Geeraerts, Zachary, Dijkhuis, Annemiek, Vught, Lonneke, Bugiani, Marianna, Lutter, René
Format:	Article
Language:	English
Subjects:	3-Hydroxyanthranilic Acid - analysis Adult Aged Anthranilic acid Apoptosis autophagy Autopsy Bioavailability brain Brain - enzymology Brain - pathology Brief Report Brief Reports Cell death Cerebrospinal fluid COVID-19 COVID-19 - enzymology COVID-19 - mortality COVID-19 - pathology COVID-19 - virology Degradation products Dioxygenase heart Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis innate_immune_response Kynurenine - analysis Lung - enzymology Lung - pathology lungs Middle Aged Morbidity Myocardium - enzymology Myocardium - pathology nucleus_of_cranial_nerve_X Pandemics Pathology Prospective Studies Quinolinic acid Quinolinic Acid - analysis Severity of Illness Index skeletal_muscle Tryptophan Tryptophan - analysis
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