Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice

Ca 2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca 2+ binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2021-11, Vol.13, p.749729
Main Authors: Climer, Leslie K., Hornak, Aubrey J., Murtha, Kaitlin, Yang, Yang, Cox, Andrew M., Simpson, Preston L., Le, Andy, Simmons, Dwayne D.
Format: Article
Language:English
Subjects:
Acoustics
Aging
Antibodies
Apoptosis
Brain stem
Ca2+ buffer
Calcium signalling
Calcium-binding protein
Cochlea
efferent
Genotype & phenotype
Hair cells
Hearing loss
knockout mice
Laboratories
Localization
Neuroscience
oncomodulin
Outer hair cells
Sound
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