Manipulation of Multiple Cell–Cell Interactions by Tunable DNA Scaffold Networks

Manipulation of cell–cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remains a challenge and missing elements. Herein, utilizing a DNA trian...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-02, Vol.61 (7), p.e202111151-n/a
Main Authors: Guo, Zhenzhen, Zhang, Lili, Yang, Qiuxia, Peng, Ruizi, Yuan, Xi, Xu, Liujun, Wang, Zhimin, Chen, Fengming, Huang, Huidong, Liu, Qiaoling, Tan, Weihong
Format: Article
Language:English
Subjects:
Aptamers
Biomedical engineering
Biomedical materials
Cell Communication
Cell Encapsulation
Cell interactions
Cell Manipulation
Cell recognition
Cell surface
Cell therapy
Cell–Cell Interactions
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA Nanotechnology
DNA Scaffold Network
HeLa Cells
Hep G2 Cells
Humans
Networks
Neural Networks, Computer
Polymers
Polymers - chemistry
Scaffolds
Tissue engineering
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Summary:Manipulation of cell–cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remains a challenge and missing elements. Herein, utilizing a DNA triangular prism (TP) and a branched polymer (BP) as functional modules, we fabricate tunable DNA scaffold networks on the cell surface. The responsiveness of cell–cell recognition, aggregation and dissociation could be modulated by aptamer‐functionalized DNA scaffold networks with high accuracy and specificity. By regulating the DNA scaffold networks coated on the cell surface, controlled intercellular molecular transportation is achieved. Our tunable network provides a simple and extendible strategy which addresses a current need in cell surface engineering to precisely manipulate cell–cell interactions and shows promise as a general tool for controllable cell behavior. A rapid and effective living cell encapsulation strategy is developed for reversible manipulation of cell–cell interactions. The controllable cell–cell interactions and molecular transportation between cells was achieved by fabricating functional DNA scaffold networks on cell surface. This DNA scaffold network‐based strategy holds great potential in cell surface engineering, synthetic biology, and cell‐based biomedicine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202111151