Four-Component Reaction Access to Nitrile-Substituted All-Carbon Quaternary Centers

A four-component reaction strategy for access to acyclic nitrile-substituted all-carbon quaternary centers is disclosed. In the presence of a DABCO-based ionic liquid catalyst, the reactions proceed smoothly with a wide range of substrates efficiently to deliver nitrile-substituted all-carbon quater...

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Bibliographic Details
Published in:Journal of organic chemistry 2022-01, Vol.87 (1), p.66-75
Main Authors: Hu, Xin, Bian, Qiang, Wang, Zheng-Lin, Guo, Lin-Jie, Xu, Yi-Ze, Wang, Ge, Xu, Da-Zhen
Format: Article
Language:English
Subjects:
Carbon
Catalysis
Molecular Structure
Nitriles
Stereoisomerism
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Summary:A four-component reaction strategy for access to acyclic nitrile-substituted all-carbon quaternary centers is disclosed. In the presence of a DABCO-based ionic liquid catalyst, the reactions proceed smoothly with a wide range of substrates efficiently to deliver nitrile-substituted all-carbon quaternary centers under mild reaction conditions. This protocol is further demonstrated as an efficient method for the construction of contiguous all-carbon quaternary centers. All the reactions are easily operated in a green manner, producing water as the only byproduct. Some of the products show excellent activity against specific fungi.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c01863