Lactiplantibacillus plantarum DMDL 9010 alleviates dextran sodium sulfate (DSS)-induced colitis and behavioral disorders by facilitating microbiota-gut-brain axis balance

Previous studies have found that probiotic supplements can ameliorate mental behavioral disorders. This study investigated the effects of DMDL 9010 (LP9010) intake on the depression-like behavior induced by dextran sodium sulfate (DSS) and its possible mechanism. Male C57BL/6N mice were fed with DSS...

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Published in:Food & function 2022-01, Vol.13 (1), p.411-424
Main Authors: Huang, Yan-Yan, Wu, Ya-Ping, Jia, Xiang-Ze, Lin, Jin, Xiao, Lan-Fang, Liu, Dong-Mei, Liang, Ming-Hua
Format: Article
Language:English
Subjects:
Animals
Behavior
Behavior, Animal - drug effects
Brain
Brain-Gut Axis - drug effects
Butyric acid
Colitis - chemically induced
Colitis - metabolism
Dextran
Dextran Sulfate - adverse effects
Dextrans
Dietary supplements
Digestive system
Disorders
Fatty acids
Gastrointestinal Microbiome - drug effects
Gastrointestinal tract
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory response
Intestinal microflora
Lactiplantibacillus plantarum
Lactobacillaceae
Male
Mental depression
Mice
Mice, Inbred C57BL
Microbiomes
Microbiota
Neurotransmitters
Probiotics
Probiotics - pharmacology
Propionic acid
Relative abundance
Sodium sulfate
Sulfates
Supplements
Ulcerative colitis
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Summary:Previous studies have found that probiotic supplements can ameliorate mental behavioral disorders. This study investigated the effects of DMDL 9010 (LP9010) intake on the depression-like behavior induced by dextran sodium sulfate (DSS) and its possible mechanism. Male C57BL/6N mice were fed with DSS to establish the model of ulcerative colitis. LP9010 intake reduced the DSS-induced inflammatory response, and repaired intestinal barrier damage, as well as lightened depression-like behavior. LP9010 supplementation also inhibited neuroinflammation by up-regulating the levels of neurotransmitters, especially 5-HT, NE, DA, and 5-HIAA. Moreover, the intake of LP9010 reorganized the gut microbiome by increasing the relative abundance of Bacteroidetes and Firmicutes, and decreasing the relative abundance of Proteobacteria and Verrucomicrobia. Furthermore, treatment with LP9010 increased the levels of short-chain fatty acids, such as butyric acid and propionic acid. In conclusion, LP9010 intake was a promising probiotic intervention strategy for the prevention of colitis-induced behavioral disorders through the microbiota-gut-brain axis.
ISSN:2042-6496
2042-650X
DOI:10.1039/d1fo02938j