Multimodal therapy for synchronous bone oligometastatic NSCLC: The role of surgery

• Published in: Journal of surgical oncology 2022-03, Vol.125 (4), p.782-789
• Main Authors: Congedo, Maria Teresa, Nachira, Dania, Bertolaccini, Luca, Chiappetta, Marco, Zanfrini, Edoardo, Meacci, Elisa, Vita, Maria Letizia, Lococo, Filippo, D'Argento, Ettore, Spaggiari, Lorenzo, Margaritora, Stefano
• Format: Article
• Language: English
• Subjects: bone metastases; Bone Neoplasms - secondary; Bone Neoplasms - surgery; Bone Neoplasms - therapy; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Carcinoma, Non-Small-Cell Lung - therapy; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lung cancer; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lung Neoplasms - therapy; lung surgery; Male; Medical prognosis; Metastasis; Middle Aged; Neoplasm Metastasis; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Neoplasms, Multiple Primary - therapy; oligometastatic NSCLC; oncological outcomes; Pneumonectomy - mortality; Prognosis; Radiation therapy; radiotherapy; Retrospective Studies; Surgery; Survival Rate
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.26773

Objectives The study aimed to assess the feasibility of radical surgical treatment for selected bone‐oligometastatic non‐small cell lung cancer (NSCLC) patients and to identify prognostic factors associated with survival. Materials and methods The clinical records of 27 patients with bone synchronous oligometastatic NSCLC were retrospectively analyzed. Results Thirteen (48.1%) bone metastases were treated by surgery and 14 (51.9%) by local radiotherapy. Eighteen (66.7%) patients underwent induction chemotherapy before lung surgery, and 3 (11.1%) concurrent radiotherapy. Pulmonary surgery was a major lung resection in 23 (85.2%) cases. Intraoperative and 30‐days mortality was null. Only one major (ARDS) and 10 (37.04%) mild complications (like air leakage, arrhythmia, and mucus retention) were recorded. 1‐year and 5‐years OS from the diagnosis and 1‐year, 3‐ years disease‐free survival (DFS) were 96%, 38%, and 66%, 30%, respectively. After stepwise Cox regression analysis, local recurrence (p = 0.05) and metachronous metastases (p = 0.04) maintained their independent prognostic value as overall survival negative determinants. Nodal upstaging (p = 0.04) and nonsurgical treatment of bone lesion (p = 0.03) turned out to be independent risk factors for shorter DFS; the vertebral localization of bone metastases showed only a remarkable trend towards significance (p = 0.06) as a risk factor for a worse DFS. Conclusions In selected patients, surgical treatment of primary NSCLC and bone synchronous metastasis seems to be safe and feasible and rewarding survivals may be expected.