Identification of Novel Biomarkers for Predicting Prognosis and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma Based on ceRNA Network and Immune Infiltration Analysis

Objectives. Patients with head and neck squamous cell carcinoma (HNSCC) have poor prognosis and show poor responses to immune checkpoint (IC) inhibitor (ICI) therapy. Competing endogenous RNA (ceRNA) networks, tumor-infiltrating immune cells (TIICs), and ICIs may influence tumor prognosis and respon...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021 (1), p.4532438
Main Authors: Guo, Ya, Pan, Wei Kang, Wang, Zhong Wei, Su, Wang Hui, Xu, Kun, Jia, Hui, Chen, Jing
Format: Article
Language:English
Subjects:
Atrophy
B-Lymphocytes - immunology
Biological markers
Biomarkers
Cancer
Care and treatment
Correlation analysis
Data analysis
Forecasts and trends
Gene expression
Genes
Genetic aspects
Head & neck cancer
Head and neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - immunology
Health aspects
Humans
Immune checkpoint
Immune system
Immunologic Factors - immunology
Immunoregulation
Immunosuppressive agents
Immunotherapy
Immunotherapy - methods
Kaplan-Meier Estimate
Leukocytes (neutrophilic)
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphocytes, Tumor-Infiltrating - immunology
Medical prognosis
Metastases
MicroRNAs
MicroRNAs - immunology
miRNA
Patient outcomes
Patients
Prognosis
Regression analysis
Response rates
Risk analysis
RNA
RNA, Long Noncoding - immunology
RNA, Messenger - immunology
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - immunology
T-Lymphocytes, Regulatory - immunology
Therapy
Tumor-infiltrating lymphocytes
Tumors
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