ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer

The HECT‐type ubiquitin E3 ligases including ITCH regulate many aspects of cellular function through ubiquitinating various substrates. These ligases are known to be allosterically autoinhibited and to require an activator protein to fully achieve the ubiquitination of their substrates. Here we demo...

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Bibliographic Details
Published in:	EMBO reports 2022-02, Vol.23 (2), p.e51182-n/a
Main Authors:	Tsunoda, Takumi, Riku, Miho, Yamada, Norika, Tsuchiya, Hikaru, Tomita, Takuya, Suzuki, Minako, Kizuki, Mari, Inoko, Akihito, Ito, Hideaki, Murotani, Kenta, Murakami, Hideki, Saeki, Yasushi, Kasai, Kenji
Format:	Article
Language:	English
Subjects:	Adaptor proteins Breast cancer Breast Neoplasms - genetics Chemokine CXCL12 Chemokine receptors Chemokines Chemotaxis Clathrin CXCL12 protein CXCR4 CXCR4 protein Desensitization EMBO03 EMBO20 EMBO31 Endocytosis Endosomes ENTREP FAM189A2 Female Gene Knockout Techniques Humans ITCH Leukocyte migration Protein transport Proteins Receptors Receptors, CXCR4 Repressor Proteins - genetics Repressor Proteins - metabolism Substrates Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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