Directed Evolution and Rational Design of Mechanosensitive Channel MscCG2 for Improved Glutamate Excretion Efficiency

Mechanosensitive amino acid exporters have drawn increasing attention due to their important roles in extracellular accumulation of the target amino acids. Protein engineering is a powerful approach to tailor the properties of amino acid exporters and illustrate structure–function relationships. Her...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry 2021-12, Vol.69 (51), p.15660-15669
Main Authors:	Nie, Zhihua, Liu, Pi, Wang, Yu, Guo, Xuan, Tan, Zijian, Shen, Jie, Tang, Zijing, Lin, Jianping, Sun, Jibin, Zheng, Ping, Zhu, Leilei
Format:	Article
Language:	English
Subjects:	Amino Acids Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Transport Biotechnology and Biological Transformations Corynebacterium glutamicum Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism directed evolution excretion fermentation food chemistry glutamic acid Glutamic Acid - metabolism molecular dynamics secretion structure-activity relationships
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