Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration

We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using -benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectiv...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2022-01, Vol.24 (1), p.309-313
Main Authors: Wang, Jin-Lin, Liu, Mei-Ling, Zou, Jian-Yu, Sun, Wen-Hui, Liu, Xue-Yuan
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using -benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c03973