Microvascular rarefaction in patients with cerebrovascular events

Capillary density rarefaction and endothelial dysfunction contribute to chronic hypoperfusion and cerebral small vessel disease. Previous animal experiments revealed spatiotemporal microvascular remodeling directing post-stroke brain reorganization. We hypothesized that microcirculatory changes duri...

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Bibliographic Details
Published in:Microvascular research 2022-03, Vol.140, p.104300-104300, Article 104300
Main Authors: Wadowski, Patricia P., Schörgenhofer, Christian, Rieder, Thomas, Ertl, Sebastian, Pultar, Joseph, Serles, Wolfgang, Sycha, Thomas, Mayer, Florian, Koppensteiner, Renate, Gremmel, Thomas, Jilma, Bernd
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Capillaries
Capillaries - pathology
Capillaries - physiopathology
Female
Hemorrhagic Stroke - diagnostic imaging
Hemorrhagic Stroke - pathology
Hemorrhagic Stroke - physiopathology
Humans
Ischemic Attack, Transient - diagnostic imaging
Ischemic Attack, Transient - pathology
Ischemic Attack, Transient - physiopathology
Ischemic stroke
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - pathology
Ischemic Stroke - physiopathology
Male
Microcirculation
Microscopy, Video
Microvascular Rarefaction
Middle Aged
Mouth Floor - blood supply
Platelet Aggregation
Prospective Studies
Sidestream darkfield videomicroscopy
Stroke
Transient ischemic attack
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Summary:Capillary density rarefaction and endothelial dysfunction contribute to chronic hypoperfusion and cerebral small vessel disease. Previous animal experiments revealed spatiotemporal microvascular remodeling directing post-stroke brain reorganization. We hypothesized that microcirculatory changes during acute cerebrovascular events could be reflected systemically and visualized sublingually. In a prospective observational trial in vivo sublingual sidestream darkfield videomicroscopy was performed in twenty-one patients with either acute stroke (n = 13 ischemic, n = 1 ischemic with hemorrhagic transformation and n = 2 hemorrhagic stroke) or transitory ischemic attacks (n = 5) within 24 h after hospital admission and compared to an age- and sex-matched control group. Repetitive measurements were performed on the third day and after one week. Functional and perfused total capillary density was rarefied in the overall patient group (3060 vs 3717 μm/mm2, p = 0.001 and 5263 vs 6550 μm/mm2, p = 0.002, respectively) and in patients with ischemic strokes (2897 vs. 3717 μm/mm2, p 
ISSN:0026-2862
1095-9319
DOI:10.1016/j.mvr.2021.104300