Applicability of the UK DCD risk score in the modern era of liver transplantation: A U.S. update

• Published in: Clinical transplantation 2022-04, Vol.36 (4), p.e14579-n/a
• Main Authors: Wu, W. Kelly, Ziogas, Ioannis A., Matsuoka, Lea K., Izzy, Manhal, Alexopoulos, Sophoclis P.
• Format: Article
• Language: English
• Subjects: Adult; Death; donation after cardiac death; Graft Survival; Humans; liver transplantation; Liver Transplantation - adverse effects; primary nonfunction; Retrospective Studies; Risk Factors; risk stratification; Tissue and Organ Procurement; Tissue Donors; United Kingdom; United Network for Organ Sharing
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14579

Background Careful graft and recipient selection have resulted in improved outcomes in liver transplantation (LT) using donation after cardiac death (DCD) organs. The UK DCD Risk Score was established as a risk stratification tool to guide selection. Methods We evaluated the applicability of the UK DCD Risk Score in a contemporary US cohort of adult DCD LT recipients using the United Network for Organ Sharing registry (2011‐2020). Results A total of 3,899 DCD LTs were included in our study (UK DCD Risk Score 0–5 points: 1,438 [36.9%], 6–10 points: 2,034 [52.2%]; 11–20 points: 427 [11.0%]). Compared to a score of 6–10 points, a score of 0–5 points was associated with decreased risk of graft loss (HR = .79, 95%CI: .68‐.93, p = .004), while a score of 11–20 points was associated with increased risk of graft loss (HR = 1.26, 95%CI: 1.01‐1.56, p = .04). The 5‐year graft survival for patients with risk scores of 0–5, 6–10, and 11–20 were 75.9%, 71.8%, and 66.5%, respectively. The C‐statistic for the UK DCD Risk Score in our contemporary cohort was .611. Conclusions The UK DCD Risk Score demonstrates a more limited ability to differentiate recipient outcomes in the modern era of DCD LT in the US. Acceptable long‐term outcomes are achievable for patients stratified to the highest‐risk group.