Enterococcus raffinosus bacteremia: clinical experience with 49 adult patients

This study is to evaluate the clinical characteristics and outcomes of Enterococcus raffinosus bacteremia in adults. We analyzed the medical records of adult patients with E. raffinosus bacteremia who were diagnosed and treated between 1997 and 2020 at a tertiary care teaching hospital in Seoul, Rep...

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Published in:European journal of clinical microbiology & infectious diseases 2022-03, Vol.41 (3), p.415-420
Main Authors: Lee, Yun Woo, Lim, So Yun, Jung, Jiwon, Kim, Min Jae, Chong, Yong Pil, Kim, Sung-Han, Lee, Sang-Oh, Kim, Yang Soo, Choi, Sang-Ho
Format: Article
Language:English
Subjects:
Adult
Ampicillin
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Bacteremia
Bacteremia - drug therapy
Bacteremia - epidemiology
Biliary tract
Biomedical and Life Sciences
Biomedicine
Enterococcus
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - epidemiology
Humans
Internal Medicine
Linezolid
Malignancy
Medical Microbiology
Medical records
Mortality
Original Article
Patients
Penicillin
Polymicrobial bacteremia
Vancomycin
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Summary:This study is to evaluate the clinical characteristics and outcomes of Enterococcus raffinosus bacteremia in adults. We analyzed the medical records of adult patients with E. raffinosus bacteremia who were diagnosed and treated between 1997 and 2020 at a tertiary care teaching hospital in Seoul, Republic of Korea. The demographic, clinical, and laboratory data were collected and assessed. A total of 49 cases of E. raffinosus bacteremia were identified. E. raffinosus accounted for 0.6% of all enterococcal bacteremia events, and the incidence was 0.02 cases per 1,000 admissions. Of the 49 cases of E. raffinosus bacteremia, 35 (71.4%) had underlying malignancy. The biliary tract was the most common source of infection (81.6%, 40/49) and polymicrobial bacteremia was found in 25 cases (51.0%). The resistance rates of E. raffinosus bacteremia cases to penicillin, ampicillin, vancomycin, and linezolid were 61.2%, 49.0%, 2.0%, and 0%, respectively. In our case series, there was one case of vanA -type vancomycin-resistant E. raffinosus . The all-cause 60-day mortality rate was 22.4% (11/49), and the E. raffinosus bacteremia-related mortality rate was 4.1% (2/49). Cases of E. raffinosus bacteremia mainly originated from biliary tract infection and had a low rate of bacteremia-related mortality.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-021-04389-x