Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

On the 24 November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with ear...

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Published in:bioRxiv 2021-12
Main Authors: Dejnirattisai, Wanwisa, Huo, Jiandong, Zhou, Daming, Zahradník, Jiří, Supasa, Piyada, Liu, Chang, Duyvesteyn, Helen M E, Ginn, Helen M, Mentzer, Alexander J, Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Dijokaite, Aiste, Khan, Suman, Avinoam, Ori, Bahar, Mohammad, Skelly, Donal, Adele, Sandra, Johnson, Sile Ann, Amini, Ali, Ritter, Thomas, Mason, Chris, Dold, Christina, Pan, Daniel, Assadi, Sara, Bellass, Adam, Omo-Dare, Nikki, Koeckerling, David, Flaxman, Amy, Jenkin, Daniel, Aley, Parvinder K, Voysey, Merryn, Clemens, Sue Ann Costa, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M, Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Madhi, Shabir, Nunes, Marta C, Malik, Tariq, Openshaw, Peter Jm, Baillie, J Kenneth, Semple, Malcolm G, Townsend, Alain R, Huang, Kuan-Ying A, Tan, Tiong Kit, Carroll, Miles W, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J, Constantinides, Bede, Webster, Hermione, Crook, Derrick, Pollard, Andrew J, Lambe, Teresa, Paterson, Neil G, Williams, Mark A, Hall, David R, Fry, Elizabeth E, Mongkolsapaya, Juthathip, Ren, Jingshan, Schreiber, Gideon, Stuart, David I, Screaton, Gavin R
Format: Article
Language:English
Subjects:
Affinity
Biotechnology
Complementarity
Insertion
Microbiology
Monoclonal antibodies
Mutation
Pandemics
Patent applications
Syncytia
Vaccine development
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