Prognostic Value of Intratumoral Collagen Quantification in Canine Oral Melanomas

The majority of the melanocytic neoplasms are considered malignant and highly metastatic. However, a subset of the melanocytic tumors has a more favorable prognosis and the identification of precise prognostic markers for this neoplasm may be useful to guide treatment. The collagen architecture and...

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Bibliographic Details
Published in:Journal of veterinary dentistry 2021-12, Vol.38 (4), p.188-192
Main Authors: Leite, Natália Goulart, Vargas, Thiago Henrique Moroni, Ferro, Daniel Giberne, Sobral, Renata Afonso, Venturini, Michèle Alice Françoise Anita, Corrêa, Herbert Lima, Strefezzi, Ricardo De Francisco
Format: Article
Language:English
Subjects:
Animals
Collagen
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Melanoma - diagnosis
Melanoma - veterinary
Mouth Neoplasms - diagnosis
Mouth Neoplasms - pathology
Mouth Neoplasms - veterinary
Prognosis
Skin Neoplasms - pathology
Skin Neoplasms - veterinary
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Summary:The majority of the melanocytic neoplasms are considered malignant and highly metastatic. However, a subset of the melanocytic tumors has a more favorable prognosis and the identification of precise prognostic markers for this neoplasm may be useful to guide treatment. The collagen architecture and density have been shown to correlate with tumor progression in human breast cancer and canine mast cell tumors. The purpose of the present study was to investigate the prognostic value of the intratumoral collagen index (ICI) as an indicator of postsurgical survival and its relation with other prognostic markers for canine oral melanomas (OMs). Twenty-two cases were tested for intratumoral collagen density using Masson's trichrome stain and morphometry. No differences were found between dogs regarding survival. The ICI was not correlated with proliferative activity or nuclear atypia. The results presented herein indicate that the quantity of intratumoral collagen in canine OMs is not an efficient indicator of postsurgical survival. Complementary studies about the expression and activity of enzymes that are capable of degrading extracellular matrix (ECM) components are necessary.
ISSN:0898-7564
2470-4083
DOI:10.1177/08987564211066638