Lifestyle changes during the coronavirus disease 2019 pandemic impact metabolic dysfunction–associated fatty liver disease

Background and Aims The coronavirus disease 2019 (COVID‐19) pandemic precipitated lifestyle changes. We aimed to clarify whether COVID‐19–induced lifestyle changes affected the development of metabolic dysfunction–associated fatty liver disease (MAFLD). Methods This retrospective longitudinal study...

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Published in:Liver international 2022-05, Vol.42 (5), p.995-1004
Main Authors: Fujii, Hideki, Nakamura, Naotoshi, Fukumoto, Shinya, Kimura, Tatsuo, Nakano, Akemi, Nadatani, Yuji, Tauchi, Yukie, Nishii, Yuuko, Takashima, Shingo, Kamada, Yoshihiro, Watanabe, Toshio, Kawada, Norifumi
Format: Article
Language:English
Subjects:
Alcohol use
body mass index
Confidence intervals
Coronaviruses
COVID-19
Fatty liver
Humans
Life Style
Lifestyles
Liver
Liver diseases
Longitudinal Studies
Metabolism
Non-alcoholic Fatty Liver Disease - complications
non‐alcoholic fatty liver disease
obesity
Pandemics
Patients
physical activity
Regression analysis
Retrospective Studies
Statistical analysis
Viral diseases
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Summary:Background and Aims The coronavirus disease 2019 (COVID‐19) pandemic precipitated lifestyle changes. We aimed to clarify whether COVID‐19–induced lifestyle changes affected the development of metabolic dysfunction–associated fatty liver disease (MAFLD). Methods This retrospective longitudinal study included 973 participants who underwent health check‐ups between 2018 and 2020. We used data from the MedCity21 health examination registry. Participants' clinical characteristics and lifestyle habits were investigated. Independent lifestyle predictors of MAFLD development before the pandemic (2018‐2019) and during the pandemic (2019‐2020) were identified using logistic regression analysis. Results In 2018, 261 (27%) patients were diagnosed with MAFLD. Before the pandemic, 22 patients developed new MAFLD. During this time, routine late‐night meals were identified as an independent lifestyle predictor of MAFLD development (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.02‐6.36, P = .046). In contrast, 44 patients developed new MAFLD during the pandemic. During this time, higher daily alcohol intake was identified as an independent lifestyle predictor of MAFLD development (HR 1.03, 95% CI 1.01‐1.05, P = .008). In participants aged
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.15158