Paediatric Cerebral Arteriovenous Malformation: Outcomes from a Singapore Children's Hospital

• Published in: Journal of stroke and cerebrovascular diseases 2022-03, Vol.31 (3), p.106283-106283, Article 106283
• Main Authors: Lim, Jia Xu, Cheong, Tien Ming, Ng, Lee Ping, Seow, Wan Tew, Chua, Felicia Hui Zhuang, Kirollos, Ramez Wadie, Low, David Chyi Yeu, Low, Sharon Yin Yee
• Format: Article
• Language: English
• Subjects: Brain arteriovenous malformation; Cerebral arteriovenous malformation in children; Child; Child, Preschool; Hospitals, Pediatric; Humans; Intracranial Arteriovenous Malformations - therapy; Paediatric cerebral arteriovenous malformation; Retrospective Studies; Singapore; Treatment Outcome; Vascular malformation
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2021.106283

Paediatric brain arteriovenous malformation (bAVM) is a rare and distinct clinical entity. There is a growing body of literature that support the success of multimodality approaches for this difficult condition. The authors aim to firstly, describe our institutional experience with a consecutive series of patients and next, corroborate our results with current literature. This is a single institution, retrospective study conducted over a 20-year period. Patients less than 19 years old with bAVM were included. Variables of interest included patient demographics, clinical presentation, neuroimaging features, bAVM characteristics and treatment modality. Functional outcomes were measured with modified Rankin scale (mRS). There were 58 paediatric bAVMs, presenting at a mean age of 8.7 ± 4.2 years, and followed up for a mean duration of 7.7 years. Thirty-six patients (62.1%) underwent microsurgical resection, 10 patients had stereotactic radiosurgery (17.2%) and 2 patients had endovascular treatment (3.4%). 50 patients (86.2%) had a favourable outcome at 1-year follow up. Microsurgical resection and SRS had similar obliteration rates (resection 83.3%; SRS 80.0%) and recurrence (resection 10.0%; SRS 12.5%). There were 6 cases of bAVM recurrence (12.8%). This subgroup was noted to be less than 7.5 years old at presentation (OR 15.0, 95% CI 1.56 – 144), and less likely to present with bAVM rupture (OR 0.11, 95% CI 0.01 – 0.96). This study describes our experience in managing paediatric bAVM, whereby monomodal therapy can still be effective. Of note, we also demonstrate the role of extended surveillance to detect recurrence.