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Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes
Aims Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes. Methods Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal...
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| Published in: | Archives of gynecology and obstetrics 2022-06, Vol.305 (6), p.1453-1463 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | de Mendonça, Elaine Luiza Santos Soares da Silva, João Victor Farias Mello, Carolina Santos de Oliveira, Alane Cabral Menezes |
| description | Aims
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Methods
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient—
r
) were applied by taking into consideration
p
|
| doi_str_mv | 10.1007/s00404-021-06313-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2618237443</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2672841466</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-64890f3a31036c76fc2051426107bf66216dc3321024481496cc74d0030e83bc3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQRi1ERUvhBVggS2zYhI49vk7uElWFIlViUVhbvs6EuiRx8DhFXfHqmN7yIxZdeew5czzSJ8QLBW8UQHvCAAZMA1o1YFFhox-JI2VQN9Aq9fif-lA8Zb4GULrr7BNxiGa7xU0HR-LHJeV1kmuOQfoQeznSDY0sPXMK0Rfq5fdYruQupnBFUwx-lIvPfqJCmeUY568VKUkumSiMflo4eslVkmO5lX6-a_q-3pnkUl9nX6ojrSWkifiZOBj8yPT8_jwWn9-dfTo9by4-vv9w-vaiCdhuSmNNt4UBPSpAG1o7BA0bZbRV0O4Ga7WyfUDUCrQxnTJbG0JregAE6nAX8Fi83nuXnL6txMVNkQONo58preyqqdPYGoMVffUfep3WPNftKtXqzihjbaX0ngo5MWca3JLj5POtU-B-xeP28bgaj7uLx-k69PJeve4m6v-M_M6jArgHuLbmL5T__v2A9idaYZqs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2672841466</pqid></control><display><type>article</type><title>Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes</title><source>Springer Link</source><creator>de Mendonça, Elaine Luiza Santos Soares ; da Silva, João Victor Farias ; Mello, Carolina Santos ; de Oliveira, Alane Cabral Menezes</creator><creatorcontrib>de Mendonça, Elaine Luiza Santos Soares ; da Silva, João Victor Farias ; Mello, Carolina Santos ; de Oliveira, Alane Cabral Menezes</creatorcontrib><description>Aims
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Methods
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient—
r
) were applied by taking into consideration
p
< 0.05 as significance level.
Results
The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (
p
= 0.014) and with primiparity (
p
= 0.007). Uric acid levels were higher in early PE cases than in late PE cases (
p
= 0.013); however, there was no significant difference between mild and severe PE cases (
p
= 0.121). Uric acid recorded a positive correlation to urea (
p
< 0.001), creatinine (
p
= 0.002), glutamic-oxaloacetic transaminase (
p
< 0.001), glutamic-pyruvic transaminase (
p
= 0.005), ferritin (
p
= 0.002) and globulin (
p
= 0.002); as well as negative correlation to platelets (
p
= 0.035), lactic dehydrogenase (
p
= 0.039) and albumin (
p
> 0.001). HU was a factor associated with cesarean delivery (
p
= 0.030), prematurity (
p
= 0.001), low birth weight (
p
< 0.001) and small for gestational age (
p
= 0.020).
Conclusion
High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.</description><identifier>ISSN: 1432-0711</identifier><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-021-06313-2</identifier><identifier>PMID: 34993580</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cross-Sectional Studies ; Endocrinology ; Female ; General Gynecology ; Gynecology ; Human Genetics ; Humans ; Hyperuricemia - complications ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Small for Gestational Age ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pre-Eclampsia ; Preeclampsia ; Pregnancy ; Uric Acid</subject><ispartof>Archives of gynecology and obstetrics, 2022-06, Vol.305 (6), p.1453-1463</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-64890f3a31036c76fc2051426107bf66216dc3321024481496cc74d0030e83bc3</citedby><cites>FETCH-LOGICAL-c375t-64890f3a31036c76fc2051426107bf66216dc3321024481496cc74d0030e83bc3</cites><orcidid>0000-0002-7497-919X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34993580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Mendonça, Elaine Luiza Santos Soares</creatorcontrib><creatorcontrib>da Silva, João Victor Farias</creatorcontrib><creatorcontrib>Mello, Carolina Santos</creatorcontrib><creatorcontrib>de Oliveira, Alane Cabral Menezes</creatorcontrib><title>Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Aims
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Methods
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient—
r
) were applied by taking into consideration
p
< 0.05 as significance level.
Results
The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (
p
= 0.014) and with primiparity (
p
= 0.007). Uric acid levels were higher in early PE cases than in late PE cases (
p
= 0.013); however, there was no significant difference between mild and severe PE cases (
p
= 0.121). Uric acid recorded a positive correlation to urea (
p
< 0.001), creatinine (
p
= 0.002), glutamic-oxaloacetic transaminase (
p
< 0.001), glutamic-pyruvic transaminase (
p
= 0.005), ferritin (
p
= 0.002) and globulin (
p
= 0.002); as well as negative correlation to platelets (
p
= 0.035), lactic dehydrogenase (
p
= 0.039) and albumin (
p
> 0.001). HU was a factor associated with cesarean delivery (
p
= 0.030), prematurity (
p
= 0.001), low birth weight (
p
< 0.001) and small for gestational age (
p
= 0.020).
Conclusion
High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.</description><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>General Gynecology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hyperuricemia - complications</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases</subject><subject>Infant, Small for Gestational Age</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pre-Eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Uric Acid</subject><issn>1432-0711</issn><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQRi1ERUvhBVggS2zYhI49vk7uElWFIlViUVhbvs6EuiRx8DhFXfHqmN7yIxZdeew5czzSJ8QLBW8UQHvCAAZMA1o1YFFhox-JI2VQN9Aq9fif-lA8Zb4GULrr7BNxiGa7xU0HR-LHJeV1kmuOQfoQeznSDY0sPXMK0Rfq5fdYruQupnBFUwx-lIvPfqJCmeUY568VKUkumSiMflo4eslVkmO5lX6-a_q-3pnkUl9nX6ojrSWkifiZOBj8yPT8_jwWn9-dfTo9by4-vv9w-vaiCdhuSmNNt4UBPSpAG1o7BA0bZbRV0O4Ga7WyfUDUCrQxnTJbG0JregAE6nAX8Fi83nuXnL6txMVNkQONo58preyqqdPYGoMVffUfep3WPNftKtXqzihjbaX0ngo5MWca3JLj5POtU-B-xeP28bgaj7uLx-k69PJeve4m6v-M_M6jArgHuLbmL5T__v2A9idaYZqs</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>de Mendonça, Elaine Luiza Santos Soares</creator><creator>da Silva, João Victor Farias</creator><creator>Mello, Carolina Santos</creator><creator>de Oliveira, Alane Cabral Menezes</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7497-919X</orcidid></search><sort><creationdate>20220601</creationdate><title>Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes</title><author>de Mendonça, Elaine Luiza Santos Soares ; da Silva, João Victor Farias ; Mello, Carolina Santos ; de Oliveira, Alane Cabral Menezes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-64890f3a31036c76fc2051426107bf66216dc3321024481496cc74d0030e83bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>General Gynecology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hyperuricemia - complications</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases</topic><topic>Infant, Small for Gestational Age</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pre-Eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Uric Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Mendonça, Elaine Luiza Santos Soares</creatorcontrib><creatorcontrib>da Silva, João Victor Farias</creatorcontrib><creatorcontrib>Mello, Carolina Santos</creatorcontrib><creatorcontrib>de Oliveira, Alane Cabral Menezes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Mendonça, Elaine Luiza Santos Soares</au><au>da Silva, João Victor Farias</au><au>Mello, Carolina Santos</au><au>de Oliveira, Alane Cabral Menezes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>305</volume><issue>6</issue><spage>1453</spage><epage>1463</epage><pages>1453-1463</pages><issn>1432-0711</issn><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Aims
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Methods
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient—
r
) were applied by taking into consideration
p
< 0.05 as significance level.
Results
The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (
p
= 0.014) and with primiparity (
p
= 0.007). Uric acid levels were higher in early PE cases than in late PE cases (
p
= 0.013); however, there was no significant difference between mild and severe PE cases (
p
= 0.121). Uric acid recorded a positive correlation to urea (
p
< 0.001), creatinine (
p
= 0.002), glutamic-oxaloacetic transaminase (
p
< 0.001), glutamic-pyruvic transaminase (
p
= 0.005), ferritin (
p
= 0.002) and globulin (
p
= 0.002); as well as negative correlation to platelets (
p
= 0.035), lactic dehydrogenase (
p
= 0.039) and albumin (
p
> 0.001). HU was a factor associated with cesarean delivery (
p
= 0.030), prematurity (
p
= 0.001), low birth weight (
p
< 0.001) and small for gestational age (
p
= 0.020).
Conclusion
High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34993580</pmid><doi>10.1007/s00404-021-06313-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7497-919X</orcidid></addata></record> |
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| issn | 1432-0711 0932-0067 1432-0711 |
| language | eng |
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| source | Springer Link |
| subjects | Cross-Sectional Studies Endocrinology Female General Gynecology Gynecology Human Genetics Humans Hyperuricemia - complications Infant, Newborn Infant, Newborn, Diseases Infant, Small for Gestational Age Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pre-Eclampsia Preeclampsia Pregnancy Uric Acid |
| title | Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes |
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