Heterogeneous vancomycin resistance in Staphylococcus aureus does not predict development of vancomycin resistance upon vancomycin pressure

Abstract Background It is unclear whether Staphylococcus aureus with heterogeneous intermediate vancomycin resistance (hVISA) can develop vancomycin resistance faster than vancomycin-susceptible S. aureus (VSSA) strains. Methods We compared the kinetics of vancomycin MIC increase for 15 days of sust...

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Published in:Journal of antimicrobial chemotherapy 2022-03, Vol.77 (4), p.1032-1035
Main Authors: Gaillard, Tiphaine, Dupieux-Chabert, Céline, Butin, Marine, Dumitrescu, Oana, Naceur, Oilida, Bouveyron, Caroline, Martra, Annie, Bes, Michèle, Tristan, Anne, Vandenesch, François, Lina, Gérard, Laurent, Frédéric, Rasigade, Jean-Philippe
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Humans
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Vancomycin - pharmacology
Vancomycin Resistance
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Summary:Abstract Background It is unclear whether Staphylococcus aureus with heterogeneous intermediate vancomycin resistance (hVISA) can develop vancomycin resistance faster than vancomycin-susceptible S. aureus (VSSA) strains. Methods We compared the kinetics of vancomycin MIC increase for 15 days of sustained in vitro vancomycin exposure for clinical hVISA (n = 12) and VSSA (n = 24) isolates, as well as for reference strains Mu3 (hVISA) and ATCC 29213 (VSSA). Clinical isolates were categorized as hVISA using the population analysis profile method. MICs were monitored for 15 days and the rate of MIC increase under exposure, for each strain, was evaluated in a linear regression model relative to time. Results All isolates acquired vancomycin resistance upon exposure. Vancomycin MICs increased faster for VSSA compared with hVISA isolates (P < 0.01). Conclusions The hVISA phenotype does not correspond to an enhanced adaptation potential to in vitro vancomycin pressure.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkab488