Comparison of Coinduction Adjuvants to Propofol in Healthy Cats Sedated With Dexmedetomidine

• Published in: Topics in companion animal medicine 2022-05, Vol.48, p.100634-100634, Article 100634
• Main Authors: Zavataro, AL, Bonatto, NCM, Julião, GH, Costa, IM, Moreira, TF, Zamboni, VAG, Floriano, BP
• Format: Article
• Language: English
• Subjects: Adjuvants; anesthesia; Anesthetic adjuvants; Animals; Benzodiazepines; Blood pressure; cat; Drug dosages; Fentanyl; General anesthesia; Heart rate; intravenous anesthesia; Intubation; Ketamine; Midazolam; Nervous system; Propofol; Recovery; Variance analysis
• ISSN: 1938-9736; 1946-9837; 1876-7613
• DOI: 10.1016/j.tcam.2022.100634

•There was no significant difference in any of the times regarding recovery from anesthesia among treatments.•Midazolam, fentanyl and ketamine are good choices as adjuvants to reduce propofol requirement during induction of anesthesia and were not associated with apnea in this study.•Propofol alone requires a significantly higher dose to produce desirable anesthesia. This study aimed to compare the effects of different coinduction agents on the duration and dose of propofol in healthy cats. Six cats aged 4.8 ± 1.0 years and weighing 4.4 ± 1.1 kg participated in 4 treatment groups of propofol combined with: saline or control group (TC); ketamine 2 mg/kg (Tket); fentanyl 1 µg/kg (Tfen); or midazolam 0.3 mg/kg (Tmid). Twenty minutes following premedication with dexmedetomidine at 10 µg/kg, induction followed the same protocol in all groups, starting with a propofol bolus of 1 mg/kg over 1 minute followed by an adjuvant, then propofol again at 1 mg/kg/minute for orotracheal intubation. Variables recorded were (in minutes): time of extubation, time to return of palpebral reflex, eye recentralization, recovery of consciousness, quadrupedal position and total propofol dose used (mg/kg). A comparison between the 4 groups was performed by analysis of variance followed by Dunnett test under 5% significance. There was no significant difference in any of the times evaluated during anesthetic recovery between the groups. The propofol dose used to allow orotracheal intubation was significantly lower in all groups compared to TC (P < .05). Ketamine, midazolam, and fentanyl are indicated as suitable choices for coinduction with propofol in cats.