Investigating default mode network connectivity disruption in children of mothers with depression

• Published in: British journal of psychiatry 2022-03, Vol.220 (3), p.130-139
• Main Authors: Zeev-Wolf, Maor, Dor-Ziderman, Yair, Pratt, Maayan, Goldstein, Abraham, Feldman, Ruth
• Format: Article
• Language: English
• Subjects: Adult; Adversity; Anxiety; Birth; Brain; Brain - diagnostic imaging; Brain research; Child; Child and Adolescent; Childbirth & labor; Childhood; Children; Children & youth; Comorbidity; Default Mode Network; Depression; Depressive Disorder, Major - diagnostic imaging; Depressive personality disorders; Developmental stages; Disruption; Emotions; Empathy; Families & family life; Female; Humans; Infancy; Infant; Infant, Newborn; Magnetic Resonance Imaging; Magnetoencephalography; Maternal depression; Mental depression; Mothers; Neural networks; Neural Pathways; Post traumatic stress disorder; Psychiatry; Psychopathology; Questionnaires; Reciprocity; Teenagers; Theta rhythms; Trauma
• ISSN: 0007-1250; 1472-1465
• DOI: 10.1192/bjp.2021.164

Exposure to maternal major depressive disorder (MDD) bears long-term negative consequences for children's well-being; to date, no research has examined how exposure at different stages of development differentially affects brain functioning. Utilising a unique cohort followed from birth to preadolescence, we examined the effects of early versus later maternal MDD on default mode network (DMN) connectivity. Maternal depression was assessed at birth and ages 6 months, 9 months, 6 years and 10 years, to form three groups: children of mothers with consistent depression from birth to 6 years of age, which resolved by 10 years of age; children of mothers without depression; and children of mothers who were diagnosed with MDD in late childhood. In preadolescence, we used magnetoencephalography and focused on theta rhythms, which characterise the developing brain. Maternal MDD was associated with disrupted DMN connectivity in an exposure-specific manner. Early maternal MDD decreased child connectivity, presenting a profile typical of early trauma or chronic adversity. In contrast, later maternal MDD was linked with tighter connectivity, a pattern characteristic of adult depression. Aberrant DMN connectivity was predicted by intrusive mothering in infancy and lower mother-child reciprocity and child empathy in late childhood, highlighting the role of deficient caregiving and compromised socio-emotional competencies in DMN dysfunction. The findings pinpoint the distinct effects of early versus later maternal MDD on the DMN, a core network sustaining self-related processes. Results emphasise that research on the influence of early adversity on the developing brain should consider the developmental stage in which the adversity occured.