Clinical study of anogenital condyloma acuminata treatment with photodynamic therapy including immunocompromised conditions

• Published in: Photodiagnosis and photodynamic therapy 2022-03, Vol.37, p.102735-102735, Article 102735
• Main Authors: Romero, M.P., Jibaja, I., Bucheli, J., Inada, N., Bagnato, V.
• Format: Article
• Language: English
• Subjects: Aminolevulinic Acid - therapeutic use; Condyloma Acuminata; Condylomata Acuminata; genital warts; HPV infections; Humans; Immunocompromised; Papillomavirus Infections - drug therapy; Photochemotherapy - methods; Photodynamic Therapy; Photodynamic Therapy low dose; Photosensitizing Agents - therapeutic use
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2022.102735

•Treatment by Photodynamic Therapy of Condyloma Acuminado caused by the Human Papilloma Virus was carried out for the first time in Ecuador. Traditional treatments for wart removal are generally focused, PDT treatment is also applied in the adjacent field where subclinical lesions may exist. This makes PDT treatment efficient and an alternative to traditional treatments. Human Papillomavirus (HPV) infection is highly prevalent worldwide, and one of its consequences is the external genital wart, or Condyloma Acuminata (CA). The present study used Photodynamic Therapy (PDT) to treat CA lesions. PDT treated 23 patients with a clinical diagnosis of multifocal and unifocal CA. Patients were divided into Group 1 (G1, Patients without pathologies associated with immunodeficiency) and Group 2 (G2, patients with pathologies associated with immunodeficiency). In the G1 group (19 patients), PDT resulted in a Complete Response in 68.4% (average 5 PDT cycles), Partial Response in 26.3% (average 10 PDT cycles), and No Response in 5.3% (average 6 PDT cycles). In the G2 group (4 patients), 100% of subjects showed a partial response (8 PDT cycles). These patients in the G2 and with partial response had associated pathologies, such as renal failure, breast cancer, and HIV. There was a slight decrease in lesions (20-40%) post-treatment in these cases. Four months after treatment, no new lesions or recurrence were observed in the entire area treated with PDT using low doses of PDT. Eighty-six percent of the patients tolerated the treatments well. We conclude that PDT is a promising and safe treatment for CA lesions compared to traditional treatments.