Association between nailfold capillaroscopy abnormalities and autoimmune disease in pediatric populations

Objective Time to diagnosis of autoimmune disease in pediatric populations can take years but nailfold capillaroscopy (NFC) may identify early signs of autoimmune disease. The aim of this study is to assess the association between nailfold capillary abnormalities and autoimmune disease in children....

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Bibliographic Details
Published in:Pediatric dermatology 2022-03, Vol.39 (2), p.197-204
Main Authors: Li, Andraia R., Burke, Connor D., Purvis, Colby S., Lee, Lara Wine
Format: Article
Language:English
Subjects:
Autoimmune diseases
Autoimmune Diseases - diagnosis
Blood vessels
Capillaries
Capillaries - abnormalities
Child
Children
connective tissue disorders
Dermatology
Diagnosis
Humans
Microscopic Angioscopy
nailfold capillaroscopy
Nails
Observational Studies as Topic
Patients
Pediatrics
skin signs of systemic disease
Systemic diseases
Vascular Malformations
video capillaroscopy
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Summary:Objective Time to diagnosis of autoimmune disease in pediatric populations can take years but nailfold capillaroscopy (NFC) may identify early signs of autoimmune disease. The aim of this study is to assess the association between nailfold capillary abnormalities and autoimmune disease in children. Methods A systematic search of PubMed, EMBASE, and Scopus was performed to identify all studies published before March 17, 2021. Observational studies reporting NFC outcomes in children with autoimmune disease and healthy controls (HC) were eligible for inclusion. Odds ratios (OR) and 95% confidence intervals (CI) were pooled using a random‐effects meta‐analytical model. Results Nine of 3665 studies reporting on 641 patients (398 subjects, 243 controls) were included. Pediatric patients with autoimmune disease were 9.88 (95% CI 3.16–30.87, I2 = 80.1%) times more likely to have abnormal nailfold capillaries than HC. Of the capillaroscopic features, dilated capillaries (OR 27.90, 95% CI 2.17–349.05, I2 = 59.9%) were the most likely abnormality observed on NFC. This was followed by the likelihood of reduced capillary density (
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.14926