Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease

The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed in all tissue and is found in both invertebrate as well as mammalian nervous systems, where it recycles various synaptic membrane proteins i...

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Bibliographic Details
Published in:Synapse (New York, N.Y.) N.Y.), 2022-03, Vol.76 (3-4), p.e22224-n/a
Main Authors: Gock, Nathan, Follett, Jordan, Rintoul, Gordon L, Beischlag, Timothy V, Lee, Frank J.S.
Format: Article
Language:English
Subjects:
Dopamine
Dopamine D1 receptors
Dopamine transporter
Homeostasis
Membrane proteins
Movement disorders
Nervous system
Neurodegenerative diseases
Neurosciences
Neurotransmission
Parkinson's disease
Protein transport
Proteins
Recycling
retromer
synapse
Synaptic transmission
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Summary:The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed in all tissue and is found in both invertebrate as well as mammalian nervous systems, where it recycles various synaptic membrane proteins including the dopamine transporter and dopamine D1 receptor, two proteins implicated in dopamine homeostasis and neurotransmission. The involvement of the retromer complex in dopamine neurobiology is further underscored by its links to Parkinson's disease, a neurodegenerative disorder of the dopamine system. In this article, the existing literature linking the retromer complex to synaptic function and dopamine homeostasis is reviewed. Additional possible links are highlighted by exploring the retromer and other Parkinson's disease‐associated proteins and possible relationships to synaptic function and dopamine transmission. The retromer complex is involved in the endosomal recycling of various cargo proteins, including the dopamine transporter (DAT) and the dopamine D1 receptor (D1DR). In this review, existing literature linking the retromer complex to synaptic function and dopamine (DA) homeostasis is discussed, while also exploring possible links to Parkinson's disease.
ISSN:0887-4476
1098-2396
DOI:10.1002/syn.22224