Resveratrol activates GABAA and/or glycine receptors on substantia gelatinosa neurons of the subnucleus caudalis in mice

Although a number of studies have reported that resveratrol has analgesic effects, the direct effect of resveratrol on substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) involved in orofacial nociceptive transmission has not been clearly examined. Thus, the objective of th...

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Bibliographic Details
Published in:Natural product research 2022-11, Vol.36 (22), p.5788-5792
Main Authors: Seon Hui Jang, Soo Joung Park, Kyoung-A, Kim, Han, Seong Kyu
Format: Article
Language:English
Subjects:
Analgesics
Desensitization
Diketones
Glycine
Glycine receptors
Neurons
Pain
Pain perception
Picrotoxin
Receptors
Resveratrol
Spinal trigeminal nucleus
Strychnine
Substantia gelatinosa
Tetrodotoxin
γ-Aminobutyric acid A receptors
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Summary:Although a number of studies have reported that resveratrol has analgesic effects, the direct effect of resveratrol on substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) involved in orofacial nociceptive transmission has not been clearly examined. Thus, the objective of this study was to investigate effects of resveratrol on SG neurons of Vc in mice using a whole-cell patch-clamp technique. Resveratrol (500 μM) induced repeatable inward currents without desensitisation. Resveratrol-induced inward currents were shown in a concentration-dependent manner. Resveratrol-induced responses were sustained in the presence of tetrodotoxin, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and DL-2-Amino-5-phosphonovaleric acid (DL-AP5). However, resveratrol-induced inward currents were suppressed in the presence of picrotoxin and strychnine. These results indicate that resveratrol can directly act on SG neurons of Vc with possible inhibitory effects on SG neurons through activation of GABAA receptors and/or glycine receptors. Thus, resveratrol can be a potential therapeutic for orofacial pain modulation.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2016746