Brain volume patterns in corticobasal syndrome versus idiopathic Parkinson's disease

Background and Purpose Patients with a corticobasal syndrome (CBS) present a rare form of atypical parkinsonism characterized by asymmetric clinical symptoms and progressive motor and nonmotor impairment, such as apraxia, alien limb phenomenon, aphasia, myoclonus, dystonia, and cognitive impairment....

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Bibliographic Details
Published in:Journal of neuroimaging 2022-07, Vol.32 (4), p.720-727
Main Authors: Ferrea, Stefano, Junker, Frederick Benjamin, Hartmann, Christian Johannes, Dinkelbach, Lars, Eickhoff, Simon B., Moldovan, Alexia Sabine, Südmeyer, Martin, Schnitzler, Alfons, Schmidt‐Wilcke, Tobias
Format: Article
Language:English
Subjects:
Aphasia
Atrophy
Basal ganglia
Brain
brain atrophy
Central nervous system diseases
Cognitive ability
Corticobasal syndrome
Dystonia
idiopathic Parkinson syndrome
Image acquisition
Impairment
Medical imaging
Morphometry
Movement disorders
Myoclonus
Neurodegenerative diseases
Neuroimaging
Parkinson's disease
Patients
Signs and symptoms
Substantia alba
voxel‐based morphometry
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Summary:Background and Purpose Patients with a corticobasal syndrome (CBS) present a rare form of atypical parkinsonism characterized by asymmetric clinical symptoms and progressive motor and nonmotor impairment, such as apraxia, alien limb phenomenon, aphasia, myoclonus, dystonia, and cognitive impairment. At early stages, clinical differentiation between CBS and idiopathic Parkinson's disease (IPD) can be challenging. Methods Using high‐resolution T1‐weighted images and voxel‐based morphometry (VBM), we sought to identify disease‐specific patterns of brain atrophy in a small sample of CBS and IPD patients at early stages of disease. We acquired MR images of 17 patients diagnosed with CBS and compared them with MR images of 17 subjects affected by IPD. Images were preprocessed and analyzed using VBM. Results When compared to each other, the CBS and IPD patients of our cohort showed differences in regional gray and white matter volume depending on the diagnosis, specifically in the superior longitudinal fascicle. Conclusions In our small patients’ group, VBM was able to detect changes in regional gray and white matter volume between patients affected by CBS and patients with IPD as early as 1.5‐2 years after the onset of the first motor symptoms.
ISSN:1051-2284
1552-6569
DOI:10.1111/jon.12971