Reflections of the sensory findings in the central nervous system in patients with neuropathic pain

This study aimed to evaluate whether there was a difference in functional magnetic resonance imaging (fMRI) findings in patients who were found having hyperalgesia or hypoesthesia according to Quantitative Sensory Tests (QST). Forty participants were included in the study: 20 with neuropathic pain (...

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Bibliographic Details
Published in:Experimental brain research 2022-04, Vol.240 (4), p.1081-1091
Main Authors: Tanigor, Goksel, Hepguler, Simin, Koken, Idris, Calli, Mehmet Cem, Uyar, Meltem
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Central Nervous System
Complications and side effects
Cortex (insular)
Cortex (somatosensory)
Functional magnetic resonance imaging
Health aspects
Humans
Hyperalgesia
Hypesthesia
Limbs
Neuralgia
Neuralgia - diagnostic imaging
Neuroimaging
Neurology
Neurosciences
Operculum
Pain
Pain Measurement - methods
Pain perception
Pain Threshold - physiology
Patient outcomes
Patients
Peripheral nerve diseases
Phenotypes
Physiological aspects
Research Article
Risk factors
Sensory evaluation
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Summary:This study aimed to evaluate whether there was a difference in functional magnetic resonance imaging (fMRI) findings in patients who were found having hyperalgesia or hypoesthesia according to Quantitative Sensory Tests (QST). Forty participants were included in the study: 20 with neuropathic pain (NP) due to cervical disc pathology (NP group) and 20 healthy volunteers. After obtaining the socio-demographic and clinical data of the participants, the painDETECT questionnaire was administered, followed by QST analysis to show the presence of hypoesthesia and/or hyperalgesia, and fMRI examinations, which included sensory stimulation of both extremities. Sensory threshold tests were found to be higher in the NP group compared with the healthy volunteers, and the heat pain threshold was found to be lower in the tests showing pain thresholds in the intergroup analyses ( p  
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-022-06315-9